基本信息
| 登记号 | CTR20233203 | 试验状态 | 进行中 |
|---|---|---|---|
| 申请人联系人 | 诺和诺德临床试验发布组 | 首次公示信息日期 | 2023-10-17 |
| 申请人名称 | 丹麦诺和诺德公司/ 诺和诺德（中国）制药有限公司/ Vetter-Pharma Fertigung GmbH & Co. KG | ||
公示的试验信息
一、题目和背景信息
| 登记号 | CTR20233203 | ||
|---|---|---|---|
| 相关登记号 | |||
| 药物名称 | NA | ||
| 药物类型 | 生物制品 | ||
| 临床申请受理号 | 企业选择不公示 | ||
| 适应症 | 用于治疗左室射血分数＞40%且hs-CRP≥2mg/L的成人症状性慢性心力衰竭。 | ||
| 试验专业题目 | HERMES：Ziltivekimab与安慰剂相比对伴系统性炎症的射血分数轻度降低或保留的心力衰竭患者患病率和死亡率的作用。 | ||
| 试验通俗题目 | HERMES - 一项旨在观察ziltivekimab与安慰剂相比在心力衰竭伴炎症患者中的作用的试验性研究。 | ||
| 试验方案编号 | EX6018-4915 | 方案最新版本号 | 2.0（中文版） |
| 版本日期: | 2023-04-25 | 方案是否为联合用药 | 否 |
二、申请人信息
| 申请人名称 | 1 2 3 | ||||
|---|---|---|---|---|---|
| 联系人姓名 | 诺和诺德临床试验发布组 | 联系人座机 | 请联系泰必达 | 联系人手机号 | 请联系泰必达 |
| 联系人Email | 请联系泰必达 | 联系人邮政地址 | 北京市-北京市-朝阳区广顺南大街8号利星行中心3号楼5层 | 联系人邮编 | 100102 |
三、临床试验信息
1、试验目的
证明在标准治疗的基础上加用ziltivekimab 15 mg s.c.每月一次与安慰剂相比在降低HFpEF伴系统性炎症受试者的CV死亡和HF事件风险方面的优效性。
2、试验设计
| 试验分类 | 安全性和有效性 | 试验分期 | III期 | 设计类型 | 平行分组 |
|---|---|---|---|---|---|
| 随机化 | 随机化 | 盲法 | 双盲 | 试验范围 | 国际多中心试验 |
3、受试者信息
| 年龄 | 18岁(最小年龄)至 无上限 (最大年龄) | ||
|---|---|---|---|
| 性别 | 男+女 | ||
| 健康受试者 | 无 | ||
| 入选标准 | 1 筛选（访视1）时血清hs-CRP≥2 mg/L 2 特定疾病-心血管 至少符合以下一种情况： a. 对于无持续性房颤/房扑患者，筛选（访视1）时的NT-proBNP≥300 pg/mL。如果筛选（访视1）时持续存在房颤/房扑，NT-proBNP必须≥600 pg/mL。 b. 筛选（访视1）前9个月内以失代偿性心力衰竭为主诊断住院或紧急/计划外就诊，且需要静脉袢利尿剂治疗的患者，如果无持续性房颤/房扑，同时满足筛选（访视1）时NT-proBNP≥200 pg/mL。如果筛选（访视1）时持续存在房颤/房扑，NT-proBNP必须≥600 pg/mL。 3 诊断为心力衰竭（NYHA分级II-IV级）。 4 筛选（访视1）前12个月内或筛选（访视1）时超声心动图记录的LVEF>40%。LVEF值必须记录在病历中，必须使用最近的测量结果确定入组资格，且期间无中期事件提示射血分数可能恶化（例如，MI或因HF住院）。 5 筛选（访视1）前12个月内或筛选（访视1）时通过超声心动图记录的结构性心脏疾病和/或功能性心脏疾病，表现为至少以下一项： a. LA容积指数>34 ml/m^2。 b. LA内径≥3.8 cm。 c. LA长径≥5.0 cm。 d. LA面积≥20 cm^2。 e. LA容积≥55 mL。 f. 室间隔厚度≥1.1 cm。 g. 后壁厚度≥1.1 cm。 h. LV质量指数≥115 g/m^2（男性）或≥95 g/m^2（女性）。 i. E/e′（平均间隔和侧壁）≥10。 j. e′（平均间隔和侧壁）<9 cm/s。 6 筛选（访视1）和随机分组（访视2）期间未因心力衰竭住院或紧急就诊。 | ||
| 排除标准 | 1 医学疾病-心血管 筛选（访视1）前30天内发生心肌梗死、卒中、不稳定型心绞痛、短暂性脑缺血发作或因心力衰竭住院。 2 筛选（访视1）时收缩压≥180 mmHg。如果收缩压为160-179 mmHg，患者应接受≥3种降压药。（注：根据研究者的判断，可在访视时间窗内重新检查潜在受试者是否符合该标准，无需重新筛选。） 3 筛选（访视1）时进行的ECG评估显示心率高于110或低于40次/分钟（注：根据研究者的判断，可在访视时间窗内重新检查潜在受试者是否符合该标准，无需重新筛选）。 4 筛选（访视1）期间已知患者计划进行冠状动脉、颈动脉或外周动脉血管重建术。（注：计划的冠状动脉造影不排除在外。） 5 筛选（访视1）期间已知患者计划进行心脏器械植入或房扑/房颤消融术。 6 随机（访视2）前60天内进行的大型心脏手术、非心脏手术或大型内窥镜术（胸腔镜或腹腔镜），或随机（访视2）时计划接受任何大型手术操作。 7 浸润性心肌病（如结节病、淀粉样蛋白）、致心律失常性右室心肌病、Takutsubo心肌病、遗传性肥厚性心肌病或梗阻性心肌病、活动性心肌炎、缩窄性心包炎、心包填塞、未经校正的中度以上原发性瓣膜疾病导致的心力衰竭。 8 原发性肺动脉高压、慢性肺栓塞、包括COPD在内的重度肺部疾病。 9 研究者判断可引起心力衰竭症状和体征的任何其他疾病（例如贫血、甲状腺功能减退症）。 10 医学疾病-感染/免疫抑制 研究者判断有活动性感染的临床证据或疑似活动性感染。 | ||
4、试验分组
| 试验药 | 序号 名称 用法 1 中文通用名:NA 英文通用名:Ziltivekimab 商品名称:NA 剂型:注射液 规格:15 mg/mL, 1 mL 用法用量:15 mg Ziltivekimab每月一次在腹部、大腿或上臂提起的皮褶处皮下注射 用药时程:估计长达4年 |
|---|---|
| 对照药 | 序号 名称 用法 1 中文通用名:Ziltivekimab安慰剂 英文通用名:Ziltivekimab placebo 商品名称:NA 剂型:注射液 规格:15 mg/mL, 1 mL 用法用量:安慰剂成分包含海藻糖二水合物、L-精氨酸单盐酸盐、L-甲硫氨酸、L-组氨酸、L-组氨酸盐酸盐一水合物、聚山梨酯80、盐酸、氢氧化钠、注射用水。15 mg Ziltivekimab每月一次在腹部、大腿或上臂提起的皮褶处皮下注射 用药时程:估计长达4年 |
5、终点指标
| 主要终点指标及评价时间 | 序号 指标 评价时间 终点指标选择 1 至首次发生复合HF终点的时间，包括： - CV死亡 - 因HF住院或紧急HF就诊 从随机分组（第0月）到研究结束（长达48个月） 有效性指标 |
|---|---|
| 次要终点指标及评价时间 | 序号 指标 评价时间 终点指标选择 1 CV死亡、因HF住院或紧急HF就诊（首次和复发）的数量 从随机分组（第0月）到研究结束（长达48个月） 有效性指标 2 至首次发生4点扩展复合HF终点的时间，该复合终点包括： - CV死亡 - 因HF住院或紧急HF就诊 - 非致死性MI - 非致死性卒中 从随机分组（第0月）到研究结束（长达48个月） 有效性指标 3 至发生CV死亡的时间 从随机分组（第0月）到研究结束（长达48个月） 有效性指标 4 至发生全因死亡的时间 从随机分组（第0月）到研究结束（长达48个月） 有效性指标 |
6、数据安全监查委员会（DMC）
有
7、为受试者购买试验伤害保险
有
四、研究者信息
1、主要研究者信息
2、各参加机构信息
| 序号 | 机构名称 | 主要研究者 | 国家或地区 | 省（州） | 城市 |
|---|---|---|---|---|---|
| 1 | 首都医科大学附属北京安贞医院 | 马长生 | 中国 | 北京市 | 北京市 |
| 2 | 重庆大学附属三峡医院 | 邵江 | 中国 | 重庆市 | 重庆市 |
| 3 | 哈尔滨医科大学附属第一医院 | 富路 | 中国 | 黑龙江省 | 哈尔滨市 |
| 4 | 海南省人民医院 | 乔平 | 中国 | 海南省 | 海口市 |
| 5 | 兰州大学第二医院 | 余静 | 中国 | 甘肃省 | 兰州市 |
| 6 | 江苏省苏北人民医院 | 顾翔 | 中国 | 江苏省 | 扬州市 |
| 7 | 中南大学湘雅三医院 | 蒋卫红 | 中国 | 湖南省 | 长沙市 |
| 8 | 中山大学孙逸仙纪念医院 | 王景峰 | 中国 | 广东省 | 广州市 |
| 9 | 暨南大学附属第一医院 | 刘福成 | 中国 | 广东省 | 广州市 |
| 10 | 陕西省人民医院 | 王军奎 | 中国 | 陕西省 | 西安市 |
| 11 | 上海市同济医院 | 赵翠梅 | 中国 | 上海市 | 上海市 |
| 12 | 辽宁省人民医院 | 侯爱洁 | 中国 | 辽宁省 | 沈阳市 |
| 13 | 南京医科大学第二附属医院 | 龙明智 | 中国 | 江苏省 | 南京市 |
| 14 | 浙江大学医学院附属第一医院 | 李闪 | 中国 | 浙江省 | 杭州市 |
| 15 | 安徽理工大学第一附属医院（淮南市第一人民医院） | 刘利军 | 中国 | 安徽省 | 淮南市 |
| 16 | 淮安市第一人民医院 | 张喜文 | 中国 | 江苏省 | 淮安市 |
| 17 | 温州医科大学附属第一医院 | 周浩 | 中国 | 浙江省 | 温州市 |
| 18 | 江苏大学附属医院 | 袁伟 | 中国 | 江苏省 | 镇江市 |
| 19 | 天津市胸科医院 | 丛洪良 | 中国 | 天津市 | 天津市 |
| 20 | 丽水市人民医院 | 梅益斌 | 中国 | 浙江省 | 丽水市 |
| 21 | 常州市第二人民医院 | 纪元 | 中国 | 江苏省 | 常州市 |
| 22 | 西安交通大学第一附属医院 | 白玲 | 中国 | 陕西省 | 西安市 |
| 23 | 四平市中心人民医院 | 房志华 | 中国 | 吉林省 | 四平市 |
| 24 | 苏州大学附属第一医院 | 蒋廷波 | 中国 | 江苏省 | 苏州市 |
| 25 | 河北省人民医院 | 党懿 | 中国 | 河北省 | 石家庄市 |
| 26 | 长沙市中心医院 | 蒋路平 | 中国 | 湖南省 | 长沙市 |
| 27 | 深圳市人民医院 | 刘华东 | 中国 | 广东省 | 深圳市 |
| 28 | 宁夏医科大学总医院 | 马学平 | 中国 | 宁夏回族自治区 | 银川市 |
| 29 | 吉林大学中日联谊医院 | 贺玉泉 | 中国 | 吉林省 | 长春市 |
| 30 | 上海市徐汇区中心医院 | 缪培智 | 中国 | 上海市 | 上海市 |
| 31 | 中日友好医院 | 孙艺红 | 中国 | 北京市 | 北京市 |
| 32 | 武汉大学人民医院 | 徐红新 | 中国 | 湖北省 | 武汉市 |
| 33 | Taipei Veterans General Hospital | Chern-En Chiang | 中国台湾 | Taiwan (Province of China) | Taipei City |
| 34 | Taipei Medical University Hospital | Chun-Yao Huang | 中国台湾 | Taiwan (Province of China) | Taipei City |
| 35 | Chang Gung Medical Foundation - Linkou Branch | Pao-Hsien Chu | 中国台湾 | Taiwan (Province of China) | Taoyuan city |
| 36 | Taichung Veterans General Hospital | Wei-Wen Lin | 中国台湾 | Taiwan (Province of China) | Taichung City |
| 37 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Tsung-Hsien Lin | 中国台湾 | Taiwan (Province of China) | Kaohsiung City |
| 38 | Nightingale Research | Andrew Hamilton | Australia | South Australia | Adelaide |
| 39 | The Canberra Hospital_Garran | Walter Abhayaratna | Australia | Australian Capital Territory | Garran |
| 40 | Royal Adelaide Hospital Cardiovascular Clinical Trials | Julie Bradley | Australia | South Australia | Adelaide |
| 41 | Flinders Medical Centre | Carmine de. Pasquale | Australia | South Australia | Bedford Park |
| 42 | Barwon Health (The Geelong Hospital) | John Amerena | Australia | VIC | Geelong |
| 43 | Concord Repatriation General Hospital - Cardiology | Andrew Sindone | Australia | New South Wales | Concord |
| 44 | Royal Hobart Hospital | Nathan Dwyer | Australia | Tasmania | Hobart |
| 45 | Gosford Hospital | Thomas Ford | Australia | New South Wales | Gosford |
| 46 | Frankston Hospital | Jamie Layland | Australia | Victoria | Frankston |
| 47 | Rhythm Heart Institute | Nirav Bhalani | India | Gujarat | Vadodara |
| 48 | CIMS- Care Institute of Medical Sciences | Urmil Shah | India | Gujarat | Ahmedabad |
| 49 | Shri B D Mehta Mahavir Heart Institute | Atul Abhyankar | India | Gujarat | Surat |
| 50 | G B Pant Institute of Postgraduate Medical Education and Res | Vimal Mehta | India | New Delhi | New Delhi |
| 51 | Sir Ganga Ram Hospital-Cardiology | Sawhney Jitendra Pal Singh | India | New Delhi | New Delhi |
| 52 | VMMC & Safdarjung Hospital | Sandeep Bansal | India | New Delhi | New Delhi |
| 53 | Lisie Hospital | Jabir Abdullakutty | India | Kerala | Kochi |
| 54 | King George’s Medical University | Bhandari Monika | India | Uttar Pradesh | Lucknow |
| 55 | Lakshmi Hospital | Jayagopal Balagopalan | India | NA | Palakkad |
| 56 | Osmania General Hospital | Krishna Malakondareddy Parvathareddy | India | Telengana | Hyderbad |
| 57 | Medanta-The Medicity | Sanjay Mittal | India | Haryana | gurugram |
| 58 | Arneja Heart & Multispeciality Hospital | Jaspal Arneja | India | MAHARASHTRA | Nagpur |
| 59 | Government Medical College and Hospital | Sunil Washimkar | India | MAHARASHTRA | Nagpur |
| 60 | B J Goverment Medical College and Sassoon General Hospital | Hemanth Kokane | India | MAHARASHTRA | Pune |
| 61 | KEM Hospital | Milind Gadakari | India | MAHARASHTRA | Pune |
| 62 | Dayanand Medical College & Hospital | Gurpreet Wander | India | Punjab | Ludhiana |
| 63 | All India Institute of Medical Sciences (AIIMS) | Rahul Choudhary | India | Rajasthan | Jodhpur |
| 64 | DR B L KAPUR MEMORIAL HOSPITAL | Satbir Singh | India | New Delhi | New Delhi |
| 65 | Sardar Vallabhbhai Patel Institute of Medical Sciences and Research | Bhupesh Shah | India | Gujarat | Ahmedabad |
| 66 | Epic Hospital | Anil Jain | India | Gujarat | Ahmedabad |
| 67 | SMS Medical College & Attached Hospitals | Chandra Bhan Meena | India | Rajasthan | Jaipur |
| 68 | Amrita Institute of Medical Sciences | Jaideep Menon | India | Kerala | Cochin |
| 69 | Shri Mahant Indiresh Hospital | Tanuj Bhatia | India | Uttarakhand | Dehradun |
| 70 | Ramesh Hospitals | Raja Ramesh Nukavarapu | India | Andhra Pradesh | Vijayawada |
| 71 | Guru Nanak Care Hospitals | Johann Christopher | India | Andhra Pradesh | Hyderabad |
| 72 | Fortis Hospital Mohali | Dr. Arun Kochar | India | Punjab | Mohali |
| 73 | Lalitha Super Specialty Hospital | Polavarapu Veera Raghava Sarma | India | Andhra Pradesh | Guntur |
| 74 | Nirmal Hospital Pvt. Ltd. | Pritesh Parekh | India | Gujarat | Surat |
| 75 | KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre | V Kothiwale | India | NA | Karnataka |
| 76 | Madras Medical Mission Hospital | Ajit Mullasari | India | Tamil Nadu | chennai |
| 77 | MS Ramaiah | UM Nagamalesh | India | NA | Bengaluru |
| 78 | Sahyadri Clinical Research And Development Center | Suhas Hardas | India | MAHARASHTRA | Pune |
| 79 | Shrikrishna Hrudayalaya and critical care centre | Mahesh Fulwani | India | MAHARASHTRA | Nagpur |
| 80 | Wonju Severance Christian Hospital | Byung Su Yoo | Korea (the Republic of) | NA | Wonju |
| 81 | Samsung Medical Center | Jin-Oh Choi | Korea (the Republic of) | Seoul | Seoul |
| 82 | Korea University Guro Hospital | Eung Ju Kim | Korea (the Republic of) | Seoul | Seoul |
| 83 | Severance Hospital, Yonsei University Health System | Chan Joo Lee | Korea (the Republic of) | Seoul | Seoul |
| 84 | Chonnam National University Hospital | Kye Hun Kim | Korea (the Republic of) | NA | Gwangju |
| 85 | Gachon University Gil Medical Center | Wook-Jin Chung | Korea (the Republic of) | NA | Incheon |
| 86 | Pusan National University Hospital | JungHyun Choi | Korea (the Republic of) | NA | Busan |
| 87 | Chungbuk National University Hospital | Ju-Hee Lee | Korea (the Republic of) | NA | Cheongju |
| 88 | Seoul National University Hospital | Hyun-Jai Cho | Korea (the Republic of) | NA | Seoul |
| 89 | Seoul National University Bundang Hospital | Dong-Ju Choi | Korea (the Republic of) | NA | Gyeonggi-do |
| 90 | University Malaya Medical Centre | Nor Ashikin Md Sari | Malaysia | NA | Kuala Lumpur |
| 91 | Hospital Sultanah Bahiyah | Abd Syukur Abdullah | Malaysia | NA | Alor Setar |
| 92 | Hospital Tengku Ampuan Afzan | Anwar Irawan Ruhani | Malaysia | NA | Kuantan |
| 93 | Universiti Teknologi MARA, Sungai Buloh Campus | Muhammad Hanis Muhmad Hamidi | Malaysia | Selangor | Sungai Buloh |
| 94 | Sarawak Heart Centre | Tiong Kiam Ong | Malaysia | Sarawak | Kota Samarahan |
| 95 | Hospital Universiti Sains Malaysia | W.Yus Haniff W.Isa | Malaysia | Kelantan | Kota Bharu |
| 96 | Hospital Universiti Kebangsaan Malaysia | Hamat Hamdi Che Hassan | Malaysia | Kuala Lumpur | Cheras |
| 97 | National Heart Centre Singapore | David Sim | Singapore | NA | Singapore |
| 98 | Sengkang General Hospital | Iswaree Balakrishnan | Singapore | NA | Singapore |
| 99 | Changi General Hospital | Zhenwei Teo | Singapore | NA | Singapore |
| 100 | National University Hospital Singapore | Weiqin Lin | Singapore | NA | Singapore |
| 101 | Khoo Teck Puat Hospital | Lee Fong Ling | Singapore | NA | Singapore |
| 102 | Cardio-Vajira | Teetouch Ananwattanasuk | Thailand | Bangkok | Bangkok |
| 103 | Chulabhorn hospital | Viroj Muangsillapasart | Thailand | NA | Bangkok |
| 104 | King Chulalongkorn Memorial Hospital | Aekarach Ariyachaipanich | Thailand | NA | Bangkok |
| 105 | Maharaj Nakorn Chiang Mai Hospital | Arintaya Phrommintikul | Thailand | NA | Chiang Mai |
| 106 | Ramathibodi Hospital-Cardiovascular metabolic Center | Prin Vathesatogkit | Thailand | NA | Bangkok |
| 107 | Thammasat University Hospital | Dilok Piyayotai | Thailand | Pathumthani | Klong Luang, Pathumthani |
| 108 | Sunpasitthiprasong Hospital | Yingsak Santanakorn | Thailand | NA | Ubon Ratchathani |
| 109 | Songklanagarind Hospital | Ply Chichareon | Thailand | Songkla | Hat Yai |
| 110 | Siriraj Hospital | Srisakul Chirakarnjanakorn | Thailand | NA | Bangkok |
| 111 | Srinagarind Hospital | Burabha Pussadhamma | Thailand | Khon Kaen | Khon Kaen |
| 112 | Justus Liebig University Giessen | Birgit Abmus | Germany | NA | Giessen |
| 113 | Hausaerztlich-Kardiologisches MVZ Am Felsenkeller GmbH | Christoph Axthelm | Germany | NA | Dresden |
| 114 | University Hospital Jena KoR | Christian Schulze | Germany | NA | Jena |
| 115 | University Medical Center Hamburg-Eppendorf | Moritz Becher | Germany | NA | Hamburg |
| 116 | Kardiologie Hassloch | Holger Killat | Germany | NA | Hassloch |
| 117 | Charite Universitatsmedizin Berlin KoR | Frank Edelmann | Germany | NA | Berlin |
| 118 | MVZ CCB Frankfurt Und Main-Taunus GbR | Holger Eggebrecht | Germany | NA | Frankfurt |
| 119 | Universitaetsmedizin Goettingen | Stephan von Haehling | Germany | NA | Gottingen |
| 120 | Zentrum fuer klinische Studien Suedbrandenburg GmbH | Andreas Hagenow | Germany | NA | Elsterwerda |
| 121 | Klinikum Der Universitat Munchen AoR | Ulrich Grabmaier | Germany | NA | München |
| 122 | St Johannes Hospital gGmbH | Helge Mollmann | Germany | NA | Dortmund |
| 123 | Universitaetsklinikum Aachen AoR | Katharina Schütt | Germany | NA | Aachen |
| 124 | Universitaetsklinikum Aachen AoR | Stefan Stork | Germany | NA | Würzburg |
| 125 | University of Leipzig | Rolf Wachter | Germany | NA | Leipzig |
| 126 | Saarland University Hospital | Bernhard Haring | Germany | NA | Homburg |
| 127 | Kardiopraxis Schirmer | Stephan H. Schirmer | Germany | NA | Kaiserslautern |
| 128 | Kardiologisch-Angiologische Praxis Herzzentrum Bremen | Jochen Müller-Ehmsen | Germany | NA | Bremen |
| 129 | Medical Center - University Of Freiburg | Dennis Wolf | Germany | NA | Freiburg |
| 130 | Al-Zoebi | Ayham Al-Zoebi | Germany | NA | Wermsdorf |
| 131 | zero PRAXEN Mannheim-Schwetzingerstadt | Peter Salbach | Germany | NA | Mannheim |
| 132 | Herzzentrum Dresden GmbH Universitaetsklinik | Ephraim Winzer | Germany | NA | Dresden |
| 133 | Kagawa Prefectural Central Hospital, Cardiovascular Medicine | Masayuki Doi | Japan | NA | Takamatsu-shi, Kagawa |
| 134 | Okayama Medical Center | Atsuyuki Watanabe | Japan | NA | Okayama |
| 135 | Yao Tokushukai General Hospital | Koshi Matsuo | Japan | NA | Osaka |
| 136 | Japan Community Health care Organization Kyushu Hospital_Cardiology | Kenji Miyata | Japan | NA | Kitakyushu-shi, Fukuoka |
| 137 | Showa University Fujigaoka Hospital_Cardiology | Mio Ebato | Japan | Kanagawa | Yokohama |
| 138 | Japan Community Health care Organization Tokuyama Community Health Center_Department of Cardiology | Takatoshi Wakeyama | Japan | NA | Yamaguchi |
| 139 | Rakuwakai Marutamachi Hospital_Cardiology | Shinichiro Yamaguchi | Japan | NA | Kyoto |
| 140 | National Hospital Organization Mito Medical Center_Cardiovascular medicine | Tomomi Koizumi | Japan | NA | Ibaraki |
| 141 | Iwate Prefectural Central Hospital | Akihiro Nakamura | Japan | NA | Morioka-shi, Iwate |
| 142 | Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology | Tomofumi Takaya | Japan | NA | Himeji-shi, Hyogo |
| 143 | National Hospital Organization Osaka National Hospital_Cardiovascular Division | Yasunori Ueda | Japan | NA | Osaka |
| 144 | Tokyo-Eki Center-building Clinic | Arihiro Kiyosue | Japan | NA | Tokyo |
| 145 | Saiseikai Suita Hospital_Cardiovascular Medicine | Kenichi Ishigami | Japan | NA | Osaka |
| 146 | Ishikawa Prefectural Central Hospital_Cardiology | Toshihiko Yasuda | Japan | NA | Ishikawa |
| 147 | Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai | Takashi Matsumoto | Japan | NA | Tokyo |
| 148 | The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine | Eisuke Amiya | Japan | NA | Bunkyo-ku, Tokyo |
| 149 | Kyushu University Hospital_Cardiovascular Medicine | Shoji Mastushima | Japan | NA | Fukuoka |
| 150 | Osaka University Hospital_Cardiovascular medicine | Yasuhiro Akazawa | Japan | NA | Osaka |
| 151 | National Hospital Organization Sendai Medical Center_Cardiovascular medicine | Noriko Onoue | Japan | NA | Miyagi |
| 152 | KKR Tohoku Kosai Hospital_Cardiology | Shu Suzuki | Japan | NA | Miyagi |
| 153 | Tohoku Medical and Pharmaceutical University Hospital_Division of Cardiology | Koji Kumagai | Japan | NA | Miyagi |
| 154 | Nagasaki Harbor Medical Center_Cardiovascular medicine | Tatsuya Nunohiro | Japan | NA | Nagasaki |
| 155 | Hamanomachi Hospital_Cardiovascular medicine | Tetsuya Shiomi | Japan | NA | Fukuoka |
| 156 | Toyama University Hospital_Internal Medicine 2 | Koichiro Kinugawa | Japan | NA | Toyama |
| 157 | Tottori University Hospital_Cardiovascular Medicine | Yoshiharu Kinugasa | Japan | NA | Tottori |
| 158 | Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center_Cardiology | Kazuki Fukui | Japan | NA | Kanagawa |
| 159 | Okayama University Hospital_Cardiovascular Medicine | Kazufumi Nakamura | Japan | NA | Okayama-shi, Okayama |
| 160 | Veritas Hospital_Cardiology | Mitsuru Tsujimoto | Japan | NA | Hyogo |
| 161 | Mitoyo General Hospital_Cardiovascular medicine | Atsushi Takaishi | Japan | NA | Kagawa |
| 162 | Uwajima City Hospital_ Cardiology | Akiyoshi Ogimoto | Japan | NA | Uwajima-shi, Ehime |
| 163 | Saiseikai Yokohamashi Nanbu Hospital_Cardiology | Tsutomu Endo | Japan | NA | Yokohama-shi, Kanagawa |
| 164 | Saga-ken Medical Centre Koseikan_Cardiology | Yutaka Hikichi | Japan | NA | Saga |
| 165 | Mie Prefectural General Medical Center_Cardiology | Jun Masuda | Japan | NA | Mie |
| 166 | Saiseikai Imabari Hospital | Tsutomu Mima | Japan | NA | Imabari-shi, Ehime |
| 167 | Kishiwada Tokushukai Hospital | Satoshi Kuroyanagi | Japan | NA | Kishiwada-shi, Osaka |
| 168 | Asahikawa-Kosei General Hospital_Cardiology | Toru Kitaoka | Japan | NA | Hokkaido |
| 169 | CEMEDIC | Claudio Majul | Argentina | NA | CABA |
| 170 | Centro de Investigaciones Médicas Clínica de Fracturas y Or | Andres Alvarisqueta | Argentina | NA | Mar del Plata |
| 171 | Instituto de Investigaciones Clinicas | Sergio Nemi | Argentina | NA | Mar del Plata |
| 172 | Centro de Investigaciones Clinica Baigorria | Juan Escalante | Argentina | Santa Fe | Granadero Baigorria |
| 173 | Centro de investigaciones Clinicas del Litoral | Miguel Hominal | Argentina | NA | Santa Fe |
| 174 | Mautalen Salud e investigación | Daniel Chirino | Argentina | Buenos Aires | CABA |
| 175 | Fundacion Favaloro | Elian Giordanino | Argentina | NA | CABA |
| 176 | DIM Clinica Privada | Oscar Montana | Argentina | NA | Buenos Aires |
| 177 | Instituto de Cardiología de Corrientes | Eduardo Perna | Argentina | NA | Corrientes |
| 178 | Instituto de Investigaciones Clinicas San Nicolás | Ruben Garcia Duran | Argentina | NA | San Nicolás |
| 179 | Hospital Italiano | Ignacio Bluro | Argentina | Argentina | Buenos Aires |
| 180 | Diabetes Heart Research Centre | Luis Noronha | Canada | Ontario | Toronto |
| 181 | Saul Vizel Pro. Med. Corp | Saul Vizel | Canada | Ontario | Cambridge |
| 182 | Dawson Clinical Research | Garry Wallace | Canada | Ontario | Guelph |
| 183 | St. Boniface Hospital | Shelley Zieroth | Canada | Manitoba | Winnipeg |
| 184 | G.A. Research Associates Ltd. | Ronald Bourgeois | Canada | New Brunswick | Moncton |
| 185 | Viacar Recherche Clinique Inc. | Francois St-Maurice | Canada | Quebec | Brossard |
| 186 | North York Diagn & Cardiac Ctr | Subodh Verma | Canada | Ontario | North York |
| 187 | University of Calgary_Calgary | Jonathan Howlett | Canada | Alberta | Calgary |
| 188 | Cambridge Cardiac Care Centre | Amritanshu- Shekhar Pandey | Canada | Ontario | Cambridge |
| 189 | Winchester Dist Memorial Hosp | Kamal Sharma | Canada | Ontario | Winchester |
| 190 | CIUSSS de l'E CHUS_Sherbrooke | Serge Lepage | Canada | Quebec | Sherbrooke |
| 191 | North Shore Heart Centre | John Vyselaar | Canada | British Columbia | North Vancouver |
| 192 | Ctr for Cardiovascular Innovation | Nathaniel Hawkins | Canada | British Columbia | Vancouver |
| 193 | Partnrs Adv Cardio Eval (PACE) | Yaariv Khaykin | Canada | Ontario | Newmarket |
| 194 | Diex Recherche Trois-Rivières | Ying Tung Sia | Canada | Québec | Trois-Rivières |
| 195 | SMH Cardiology Clinical Trials Inc. | Tarun Sharma | Canada | British Columbia | Surrey |
| 196 | Royal Columbian Hospital | Razi Khan | Canada | British Columbia | New Westminster |
| 197 | St. Joseph's Hospital | Neville Suskin | Canada | Ontario | London |
| 198 | CHU de Montréal | Samer Mansour | Canada | Quebec | Montréal |
| 199 | Kawartha Cardiology Clinical Trials | Michael Hartleib | Canada | Ontario | Peterborough |
| 200 | Nova Scotia Health | Kim Anderson | Canada | Nova Scotia | Halifax |
| 201 | CPS Research | Amelia Yip | Canada | Ontario | Waterloo |
| 202 | Clinical Research Solutions Inc. | Shivinder Jolly | Canada | Ontario | Waterloo |
| 203 | Hamilton Hlth Sc. - General Site | Catherine Demers | Canada | Ontario | Hamilton |
| 204 | St. Michael's Hospital_Toronto | Gordon Moe | Canada | Ontario | Toronto |
| 205 | Alta Clinical Research | Allan Kelly | Canada | Alberta | Edmonton |
| 206 | Victoria Heart Institute Foundation | Elizabeth Swiggum | Canada | British Columbia | Victoria |
| 207 | Ctr de méd métab de Lanaudière | Yves Robitaille | Canada | Quebec | Terrebonne |
| 208 | Royal University Hospital | Alexander Zhai | Canada | Saskatchewan | Saskatoon |
| 209 | CardioVasc HR Inc | Daniel Savard | Canada | Quebec | St. Jean sur Richelieu |
| 210 | Centricity Rsrch Oshawa Multispecialty | Rishi Handa | Canada | Ontario | Oshawa |
| 211 | Health Sciences North Rsrch Inst | Atilio Costa-Vitali | Canada | Ontario | Sudbury |
| 212 | Women's College Hospital | Jacob Udell | Canada | Ontario | Toronto |
| 213 | St Pauls Hospital | Mustafa Toma | Canada | British Columbia | Vancouver |
| 214 | Institut de Cardiologie de Montreal | Eileen OMeara | Canada | Quebec | Montreal |
| 215 | Herlev og Gentofte Hospital | Morten Schou | Denmark | NA | Herlev |
| 216 | Aarhus Universitetshospital, Skejby Hjertesygdomme | Henrik Wiggers | Denmark | NA | Aarhus N |
| 217 | Bispebjerg og Frederiksberg Hospital | Christian Tuxen | Denmark | NA | Frederiksberg |
| 218 | Sjallands Universitetshospital_Roskilde | Niels Bruun | Denmark | NA | Roskilde |
| 219 | Kardiologisk Odense & Svendborg | Kenneth Egstrup | Denmark | Region south | Svendborg |
| 220 | TYKS Sydankeskus | Heikki Ukkonen | Finland | NA | Turku |
| 221 | StudyCor | Kai Nyman | Finland | NA | Jyvaskyla |
| 222 | Health Step Finland Oy | Timo Lakka | Finland | NA | Kuopio |
| 223 | Seinajoen keskussairaala | Tiina Keski-Opas | Finland | NA | Seinajoki |
| 224 | TAYS Sydansairaala | Essi Ryodi | Finland | NA | Tampere |
| 225 | Erasmus MC | Rudolf De Boer | Netherlands (the) | NA | Rotterdam |
| 226 | Treant zorggroep | Lennaert Kleijn | Netherlands (the) | NA | Emmen |
| 227 | Medisch Spectrum Twente | Mieke Van den Heuvel | Netherlands (the) | NA | Enschede |
| 228 | Deventer Ziekenhuis | W. Jansen Klomp | Netherlands (the) | NA | Deventer |
| 229 | Maastricht Universitair Medisch Centrum | Vanessa Van Empel | Netherlands (the) | NA | Maastricht |
| 230 | Albert Schweitzer Ziekenhuis locatie Dordwijk | Marco Van Gent | Netherlands (the) | NA | Dordrecht |
| 231 | UMC Groningen | Adriaan Voors | Netherlands (the) | NA | Groningen |
| 232 | Zuyderland ziekenhuis | Sandra Van Wijk | Netherlands (the) | NA | Heerlen |
| 233 | Haga Ziekenhuis | Jan Willem Borleffs | Netherlands (the) | NA | Den Haag |
| 234 | CHLO, EPE - Hospital Sao Francisco Xavier | Maria Candida Fonseca | Portugal | NA | Lisbon |
| 235 | Centro Hospitalar Lisboa Norte | Dulce Brito | Portugal | NA | Lisboa |
| 236 | Centro Hospitalar do Porto, E.P.E | Irene Marques | Portugal | NA | Porto |
| 237 | CHTamega e Sousa - Hospital Padre Américo | Aurora Andrade | Portugal | NA | Guilhufe – Penafiel |
| 238 | Hospital da Luz | Pedro Sarmento | Portugal | NA | Lisboa |
| 239 | Centro Hospitalar de Setubal | Sara Goncalves | Portugal | NA | Setubal |
| 240 | Hospital Universitario de Gran Canaria Doctor Negrín | Antonio García Quintana | Spain | NA | Las Palmas de Gran Canaria |
| 241 | Clínica Nuevas Tecnologías en Diabetes y Endocrinología | Silvia Gómez Moreno | Spain | NA | Sevilla |
| 242 | Hospital Germans Trias i Pujol | Antonio Bayes | Spain | Barcelona | Badalona |
| 243 | Hospital de Bellvitge | Cristina Enjuanes | Spain | NA | L'Hospitalet de Llobregat |
| 244 | Hospital Ramón y Cajal | Marta Jiménez Blanco | Spain | Madrid | Madrid |
| 245 | Hospital Clinico San Carlos | Alejandra Restrepo | Spain | Madrid | Madrid |
| 246 | Hospital Universitario Puerta de Hierro Majadahonda | Marta Cobo Marcos | Spain | Madrid | Madrid |
| 247 | University Clinical Centre of the Republic Srpska | Tamara Kovacevic Preradovic | Bosnia and Herzegovina | NA | Banja Luka |
| 248 | University Clinical Centre Sarajevo | Alden Begic | Bosnia and Herzegovina | NA | Sarajevo |
| 249 | Dr. Abdulah Nakas General Hospital | Denis Mackic | Bosnia and Herzegovina | NA | Sarajevo |
| 250 | Medical Center ISUL | Assen Goudev | Bulgaria | Sofia | Sofia |
| 251 | Diagnostic - Consulting Center Aleksandrovska EOOD | Nikolay Runev | Bulgaria | Sofia | Sofia |
| 252 | MHAT | Bojidar Dimov | Bulgaria | Sofia | Sofia |
| 253 | UMHAT Heart and Brain | Iana Simova | Bulgaria | NA | Pleven |
| 254 | Diagnostic Consulting Center Ascendent | Ivaylo Ivanov | Bulgaria | Sofia | Sofia |
| 255 | MHAT Hearth and brain EAD | Lilyana Mircheva | Bulgaria | NA | Burgas |
| 256 | National Multiprofile Transport Hospital | Valentina Mincheva-Kabakchieva | Bulgaria | NA | Sofia |
| 257 | Medical center Zara-Med EOOD | Vladimir Zhelev | Bulgaria | NA | Stara Zagora |
| 258 | UMHAT Sveti Georgi EAD | Krasimir Dzhinsov | Bulgaria | Plovdiv | Plovdiv |
| 259 | MDHAT | Haralambi Benov | Bulgaria | Veliko Tarnovo | Veliko Tarnovo |
| 260 | Medical centre | Ralitsa Vatova-Bialetska | Bulgaria | Kozloduy | Kozloduy |
| 261 | MHAT - UniHospital OOD | Irina Ganeva-Karadzhova | Bulgaria | Panagyurishte | Panagyurishte |
| 262 | Medical centre Health Care OOD | Chavdar Velikov | Bulgaria | Sandanski | Sandanski |
| 263 | Medical center Medconsult Pleven OOD | Maria Tzekova | Bulgaria | Pleven | Pleven |
| 264 | Diagnostic Consulting Center 1- Lom EOOD | Dilyan Simeonov | Bulgaria | Lom | Lom |
| 265 | Medical Center Hipokrena EOOD | Tanya Petkova | Bulgaria | Sevlievo | Sevlievo |
| 266 | Clinical Hospital Centre Osijek | Kristina Selthofer Relatic | Croatia | 31000 Osijek | Osijek |
| 267 | University Hospital Centre Zagreb | Maja Cikes | Croatia | Grad Zagreb | Zagreb |
| 268 | Specijalna bolnica Krapinske Toplice - Kardiologija | Krunoslav Fuckar | Croatia | Krapinsko zagorska county | Krapinske Toplice |
| 269 | KBC Split | Darija Bakovic Kramaric | Croatia | 21000 Croatia | Split |
| 270 | University Hospital Centre Zagreb | Davor Milicic | Croatia | Grad Zagreb | Zagreb |
| 271 | Clinical Hospital Dubrava | Jasmina Catic | Croatia | Grad Zagreb | Zagreb |
| 272 | KBC Rijeka, Zavod za kardiomiopatije | Koraljka Benko | Croatia | NA | Rijeka |
| 273 | Poliklinika Solmed | Vjekoslav Radeljic | Croatia | Grad Zagreb | Zagreb |
| 274 | Opca bolnica Karlovac | Kamal Al Rajabi | Croatia | NA | Karlovac |
| 275 | Poliklinika Magnolija | Darko Pocanic | Croatia | NA | Zagreb |
| 276 | Kardiologie Trutnov Ferkl | Richard Ferkl | Czechia | NA | Trutnov |
| 277 | Vseobecna kardiologicka ambulance | Ladislav Kuchar | Czechia | NA | Tabor |
| 278 | Nemocnice Slany Kardiologie | Ondrej Cermak | Czechia | NA | Slany |
| 279 | Policska nemocnice | Pavel Koleckar | Czechia | NA | Policka |
| 280 | Clinical Trials Service s.r.o. | Vladimír Cech | Czechia | NA | Uherske Hradiste |
| 281 | KARDIOLOGIE - LIBEREC s.r.o. | David Horák | Czechia | NA | Liberec |
| 282 | Fakultni nemocnice Plzen - Lochotin | Milan Hromadka | Czechia | NA | Plzen - Lochotín |
| 283 | Fakultní poliklinika VFN ambulance Srdecniho selhani | Daniel Rob | Czechia | NA | Praha 2 |
| 284 | Kardiologická a interní ambulance | Vladimír Hrabos | Czechia | NA | Praha 1 |
| 285 | FN Hradec Kralove | Radek Pudil | Czechia | NA | Hradec Kralove |
| 286 | Alexandra General Hospital, Therapeutic Clinic | Alexandros Briasoulis | Greece | Attiki | Athens |
| 287 | Hygeia General Hospital of Athens | Elias Tsougos | Greece | NA | Athens |
| 288 | General University Hospital of Patras | Periklis Davlouros | Greece | NA | Rio Patras |
| 289 | G. Gennimatas General Hospital of Athens | Apostolos Karavidas | Greece | NA | Athens |
| 290 | Ippokrateio General Hospital of Thessaloniki | Vassilios Vassilikos | Greece | NA | Thessaloniki |
| 291 | Sotiria Thoracic Diseases Hospital of Athens | Gerasimos Siasos | Greece | NA | Athens |
| 292 | Univ Gen Hospital Larisa, Internal Medicine Clinic | Grigorios Giamouzis | Greece | NA | Larissa |
| 293 | General Hospital of Chios Skilitsio | Athanasios Kartalis | Greece | NA | Chios |
| 294 | Konstantopouleio G.H. of Athens, Agia Olga | Sotirios Patsilinakos | Greece | NA | Athens |
| 295 | Genl Hospital of Athens Ippokrateio, A Cardiology Univ dpt | Konstantinos Tsioufis | Greece | NA | Athens |
| 296 | Iatriko Athinon (Athens Medical Canter) | Fotios Tsakalis | Greece | NA | Athens |
| 297 | AHEPA University General Hospital of Thessaloniki | Georgios Giannakoulas | Greece | NA | Thessaloniki |
| 298 | U.G.H of Athens Attikon | Gerasimos Filippatos | Greece | NA | Chaidari, Athens |
| 299 | Periphery University Hospital of Heraklion | Georgios Kohiadakis | Greece | Crete | Heraklion |
| 300 | Iatriko Athinon (Athens Medical Canter) | Vlasis Ninios | Greece | NA | Pylea, Thessaloniki |
| 301 | PTE AOK I. sz. Belgyogyaszati Klinika | Robert Halmosi | Hungary | Baranya megye | Pecs |
| 302 | Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Noemi Nyolczas | Hungary | Budapest | Budapest |
| 303 | Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszat | Bela Merkely | Hungary | Budapest | Budapest |
| 304 | Selye Janos Korhaz | Imre Szakal | Hungary | Komarom-Esztergom | Komarom |
| 305 | Lausmed Kft. | Laszlo Konyves | Hungary | Bacs-Kiskun | Baja |
| 306 | Somogy Megyei Kaposi Mor Oktato Korhaz | Andras Vorobcsuk | Hungary | Somogy megye | Kaposvar |
| 307 | Szegedi Tudomanyegyetem II. sz Belgyogyaszati es Kardiologia | Attila Farkas | Hungary | Csongrad-Csanad | Szeged |
| 308 | Dr. Nagy Laszlo Kardiologiai – Belgyogyasz – Diabetologiai maganrendeles | Laszlo Nagy | Hungary | Bekes megye | Oroshaza |
| 309 | Jahn Ferenc Del-pesti Korhaz es Rendelointezet | Jozsef Lippai | Hungary | Budapest | Budapest |
| 310 | Leda Platan Maganklinika | Geza Lupkovics | Hungary | Zala megye | Zalaegerszeg |
| 311 | Dr. Lakatos Ferenc Kardiologus ,Belgyogyasz Magan szakrendeles | Ferenc Lakatos | Hungary | Bekes megye | Bekescsaba |
| 312 | Sheba Medica Center - Clinical Research Unit | Michael Shechter | Israel | NA | Tel Hashomer |
| 313 | Cardio Vascular Research Center Sourasky MC | Yaron Arbel | Israel | NA | Tel Aviv |
| 314 | Heart Failure Unit, Rabin Medical Center - Beilinson Campus | Tuvia Ben-Gal | Israel | NA | Petah-Tikva |
| 315 | Shamir (Assaf Harofe) Medical Center | Gil Moravsky | Israel | NA | Zrifin |
| 316 | Hadassah MC - Cardio | Israel Gotsman | Israel | NA | Jerusalem |
| 317 | Heart failure unit Rambam Medical center | Oren Caspi | Israel | NA | Haifa |
| 318 | Kaplan Medical Center | Sorel Goland | Israel | NA | Rehovot |
| 319 | Spedali Civili Brescia | Marco Metra | Italy | Bs | Brescia |
| 320 | Azienda Ospedaliero-Universitaria Renato Dulbecco | Angela Sciacqua | Italy | Cz | Catanzaro |
| 321 | Azienda Ospedaliera Universitaria Senese | Matteo Cameli | Italy | SI | Siena |
| 322 | ASST Papa Giovanni XXIII | Michele Senni | Italy | BG | Bergamo |
| 323 | AOUI Verona | Mauro Zamboni | Italy | Vr | Verona |
| 324 | A.O.U. Ferrara, Sant Anna | Alessandro Fucili | Italy | Fe | Cona (Ferrara) |
| 325 | AORN San Pio - Benevento | Marino Scherillo | Italy | Bn | Benevento |
| 326 | AORN Sant Anna e San Sebastiano | Paolo Calabro | Italy | CE | Caserta |
| 327 | Azienda Ospedaliera di Rilievo Nazionale AORN Dei Colli, V.Monaldi | Paolo Golino | Italy | NA | Napoli |
| 328 | Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia | GIUSEPPE MUSUMECI | Italy | TO | TORINO |
| 329 | Fondazione IRCCS Policlinico San Matteo | Annalisa Turco | Italy | NA | Pavia |
| 330 | Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara | Giuseppe Patti | Italy | No | Novara |
| 331 | Azienda Sanitaria Univ Giuliano Isontina | Marco Merlo | Italy | NA | Trieste |
| 332 | Azienda Sanitaria Locale To3 Ospedale degli infermi di Rivoli | Greca Zanda | Italy | TO | Rivoli |
| 333 | IRCCS Azienda Ospedaliero Universitaria San Martino - IST | Italo Porto | Italy | GE | Genova |
| 334 | Fondazione CNR-Regione Toscana Gabriele Monasterio | Michele Emdin | Italy | PI | Pisa |
| 335 | Ospedale Santo Spirito | Federico Nardi | Italy | Al | Casale Monferrato |
| 336 | Azienda Ospedaliera di Perugia Ospedale S. Maria della Miser | Matteo Pirro | Italy | Pg | Perugia |
| 337 | Ospedale San Filippo Neri | Furio Colivicchi | Italy | RM | Roma |
| 338 | Ospedali riuniti di Foggia | Natale Brunetti | Italy | NA | Foggia |
| 339 | Riga East Clinical University Hospital - Clinic | Artis Kalnins | Latvia | Riga | Riga |
| 340 | P. Stradins Clinical University Hospital | Gustavs Latkovskis | Latvia | Riga | Riga |
| 341 | Adoria | Arija Lace | Latvia | Riga | Riga |
| 342 | Riga 1st Hospital | Ilze Reinholde | Latvia | Riga | Riga |
| 343 | GK Neiroklinika | Nikolajs Sorokins | Latvia | Riga | Riga |
| 344 | Klinikiniai sprendimai, Kaunas | Rimvydas Slapikas | Lithuania | NA | Kaunas |
| 345 | JSC Saules seimos medicinos centras | Gediminas Urbonas | Lithuania | NA | Kaunas |
| 346 | Klaipeda university hospital Affiliate Seamen's Hospital | Sigute Norkiene | Lithuania | NA | Klaipeda |
| 347 | Republican Siauliai Hospital Consulting Outpatient Clinic | Jelena Celutkiene | Lithuania | NA | Siauliai |
| 348 | JSC Inlita Santaros | Gitana Zuoziene | Lithuania | NA | Vilnius |
| 349 | MediNess Sp. z o.o. | Jadwiga Nessler | Poland | Malopolskie | Cracow |
| 350 | Pro Familia Altera Sp. z o.o. | Danuta Wronska | Poland | Slaskie | Katowice |
| 351 | Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio | Anna Tomaszuk-Kazberuk | Poland | Podlaskie | Bialystok |
| 352 | UniCardia & UniMedica & UniEstetica | Grzegorz Gajos | Poland | NA | Krakow |
| 353 | Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman | Krzysztof Cymerman | Poland | NA | Gdynia |
| 354 | American Heart of Poland S.A. | Maciej Kosmider | Poland | lodzkie | Belchatow |
| 355 | Wojewodzki Specjalistyczny Szpital im.Wl. Bieganskiego, | Jaroslaw Kasprzak | Poland | NA | Lodz |
| 356 | American Heart of Poland S.A. | Aleksander Zurakowski | Poland | Malopolskie | Chrzanow |
| 357 | American Heart of Poland S.A. | Adam Janas | Poland | Slaskie | Tychy |
| 358 | American Heart of Poland S.A. | Katarzyna Szymczyk | Poland | Slaskie | Dabrowa Gornicza |
| 359 | 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu | Bartosz Krakowiak | Poland | dolnoslaskie | Wroclaw |
| 360 | Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego | Joanna Szachniewicz | Poland | dolnoslaskie | Wroclaw |
| 361 | Uniwersytecki Szpital Kliniczny Im Wojskowej Akademii Medycznej Centralny Szpital Weteranow | Malgorzata Lelonek | Poland | lodzkie | Lodz |
| 362 | 浙江省人民医院 | 王利宏 | 中国 | 浙江省 | 杭州市 |
| 363 | 广西壮族自治区人民医院 | 吉庆伟 | 中国 | 广西壮族自治区 | 南宁市 |
| 364 | 复旦大学附属华山医院 | 包丽雯 | 中国 | 上海市 | 上海市 |
| 365 | Praktyka Lekarska-Tomasz Borkowski | Tomasz Borkowski | Poland | kujawsko-pomorskie | Wloclawek |
| 366 | Wojskowy Instytut Medyczny | Pawel Krzesinski | Poland | NA | Warszawa |
| 367 | SAMODZIELNY PUBLICZNY SZPITAL KLINICZNY IM. PROF. W. ORLOWSKIEGO CENTRUM MEDYCZNEGO KSZTALCENIA PODYPLOMOWEGO | Piotr Jankowski | Poland | mazowieckie | Warszawa |
| 368 | Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu | Lukasz Wisniowski | Poland | NA | Przemysl |
| 369 | Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II | Janusz Bednarski | Poland | NA | Grodzisk Mazowiecki |
| 370 | Gornoslaskie Centrum Medyczne Im Prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego W Katowicach | Krystian Wita | Poland | Silesian Voivodeship | Katowice |
| 371 | Instytut Centrum Zdrowia Matki Polki | Agata Bielecka Dabrowa | Poland | NA | Lodz |
| 372 | Specjalistyczna Praktyka Lekarska L. Bryniarski | Leszek Bryniarski | Poland | NA | Krakow |
| 373 | Aka-Med Centrum | Janusz Spyra | Poland | Silesian Voivodeship | Ruda Slaska |
| 374 | Wojewodzki Szpital Zespolony Im.L.Rydygiera W Toruniu | Grzegorz Skonieczny | Poland | Kuyavian-Pomeranian Voivodeship | Torun |
| 375 | Slaskie Centrum Chorob Serca W Zabrzu | Piotr Rozentryt | Poland | slaskie | Zabrze |
| 376 | Panek Med Centrum Leczenia Chorob Naczyn | Anna Lisowska | Poland | Podlaskie Voivodeship | Bialystok |
| 377 | ZDROWIE S.C. AGNIESZKA I DONALD DROZDZ | Donald Drozdz | Poland | dolnoslaskie | Wroclaw |
| 378 | American Heart of Poland S.A. | Nader Elmasri | Poland | NA | Sztum |
| 379 | American Heart of Poland S.A. | Jakub Forys | Poland | Lodz Voivodeship | Zgierz |
| 380 | Centrul Medical Emerald | Maria Dorobantu | Romania | NA | Bucuresti |
| 381 | Mat Cord Biomedica S.R.L. | Florin Matei | Romania | Buzau | Buzau |
| 382 | CMI Dr. Cristian Podoleanu | Cristian Podoleanu | Romania | NA | Tirgu Mures |
| 383 | Cabinet Medical de Cardiologie Dr. Calin Pop | NA | Romania | NA | Baia Mare |
| 384 | Institutul de Boli Cardiovasculare Timisoara | Dan Gaita | Romania | NA | Timisoara |
| 385 | SC SAL MED SRL | Gabriela Stanciulescu | Romania | NA | Pitesti |
| 386 | Cardiomed SRL | Constantin Militaru | Romania | NA | Craiova |
| 387 | Spitalul Universitar de Urgenta Bucuresti | Dragos Vinereanu | Romania | NA | Bucuresti |
| 388 | Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed | Sanziana Barbulescu | Romania | Brasov | Brasov |
| 389 | Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta | Irinel Parepa | Romania | NA | Constanta |
| 390 | Neurocord Medical SRL | Alina Giuca | Romania | Craiova | Craiova |
| 391 | Spitalul Judetean de Urgenta Braila | Luminita Serban | Romania | NA | Braila |
| 392 | Spitalul Universitar de Urgenta Elias | Andreea Popescu | Romania | NA | Bucuresti |
| 393 | Hightech Medical Services S.R.L. | Simona Almarichi-Vlad | Romania | NA | Bucuresti |
| 394 | Spitalul Clinic Municipal de Urgenta Timisoara | Daniel Lighezan | Romania | NA | Timisoara |
| 395 | DAVIUS CLINICMED SRL | Alina Dumitrascu | Romania | NA | Bucharest |
| 396 | Spitalul Clinic Judetean de Urgenta Targu Mures | Theodora Benedek | Romania | NA | Targu Mures |
| 397 | SC Consultmed SRL | Daniela Crisu | Romania | NA | Iasi |
| 398 | Bella Praxis S.R.L. | Bogdan Brinza | Romania | NA | Pascani |
| 399 | Institutul de Boli Cardiovasculare Prof. Dr. George I.M. Georgescu | Cristian Statescu | Romania | NA | Iasi |
| 400 | Donna Medplus S.R.L. | Oana Gheorghe-Fronea | Romania | NA | Bucuresti |
| 401 | SC Diamed Obesity SRL | Magdalena Morosanu | Romania | Galati | Galati |
| 402 | Lotus Med SRL | Adela Mohanu | Romania | NA | Bucuresti |
| 403 | ECOCARD SRL | Maria Dorobantu | Romania | NA | Bucuresti |
| 404 | CARDIO D&R, s.r.o. | Jan Fedacko | Slovakia | Slovakia | Kosice |
| 405 | Interna SK s.r.o. | Peter Fulop | Slovakia | Presovsky kraj | Svidnik |
| 406 | Nemocnica S Poliklinikou Brezno N.O. | Lubomir Antalik | Slovakia | Banskobystricky kraj | Brezno |
| 407 | MEDIVASA, s.r.o., Kardiologicka ambulancia 1, 2 | Viliam Bugan | Slovakia | Slovakia | Zilina |
| 408 | Intradia s.r.o. | Peter Kois | Slovakia | Slovakia | Nitra |
| 409 | Fakultna Nemocnica Trnava | Silvia Hojerova | Slovakia | Slovakia | Trnava |
| 410 | KARDIO-SANUS, spol. s r.o. | Jaroslava Strbova | Slovakia | Slovakia | Bratislava |
| 411 | Raslouw Private Hospital | Iftikhar Ebrahim | South Africa | Gauteng | Pretoria |
| 412 | Cardiac Clinical Research Unit, University of Cape Town | Mpiko Ntsekhe | South Africa | Western Cape | Cape Town |
| 413 | WITS Clinical Research | Nqoba Tsabedze | South Africa | Gauteng | Johannesburg |
| 414 | Dr Hendrik Snyman's Practice | Hendrik Snyman | South Africa | Western Cape | Mossel Bay |
| 415 | Tread Research (Pty)Ltd | Lesley Burgess | South Africa | Western Cape | Cape Town |
| 416 | IATROS International | Nyda Fourie | South Africa | Free State | Bloemfontein |
| 417 | Wits Bara Clinical Trial Site | Aysha Badat | South Africa | Gauteng | Johannesburg |
| 418 | Dr Corbett | Clive Corbett | South Africa | Western Cape | Cape Town |
| 419 | Lenasia Clinical Trial Centre | Riaz Dawood | South Africa | Gauteng | Lenasia |
| 420 | Dr Garda Cardiology Practice | Soraya Cassimjee | South Africa | Gauteng | Johannesburg |
| 421 | RYEXO Clinical Research | Larry Mey | South Africa | Gauteng | Pretoria |
| 422 | Johese Clinical Research | Jean Vorster | South Africa | Gauteng | Centurion |
| 423 | Clinical Projects Research | Louis Van Zyl | South Africa | Western Cape | Worcester |
| 424 | KwaPhila Health Solutions | Haroon Mia | South Africa | KwwaZulu Natal | Durban |
| 425 | Synexus Helderberg Clinical Research Centre | Dorothea Urbach | South Africa | Western Cape | Cape Town |
| 426 | Dr Mpe's Practice | Martin Mpe | South Africa | Gauteng | Pretoria |
| 427 | Synexus Watermeyer Clinical Research Centre | Elmien Malherbe | South Africa | Gauteng | Pretoria |
| 428 | Tiervlei Trial Centre | Matthys Basson | South Africa | Western Cape | Cape Town |
| 429 | The Research Group of Lexington LLC | Mubashir Qazi | United States of America (the) | Kentucky | Lexington |
| 430 | PharmaTex Research, LLC | David Brabham | United States of America (the) | Texas | Amarillo |
| 431 | Stony Brook University Hospital | Hal Skopicki | United States of America (the) | New York | Stony Brook |
| 432 | Trinity Health Michigan Heart | Mansoor Qureshi | United States of America (the) | Michigan | Ypsilanti |
| 433 | Heart Grp_ Lancaster Gen Hlth | Amit Varma | United States of America (the) | Pennsylvania | Lancaster |
| 434 | MD Medical Research | Stephanie Meller | United States of America (the) | Maryland | Oxon Hill |
| 435 | Eastern Shore Rsrch Inst, LLC | Michael Pursley | United States of America (the) | Alabama | Fairhope |
| 436 | Carteret Medical Group | Mary Lawrence | United States of America (the) | North Carolina | Morehead City |
| 437 | Baptist Health Research Institute | Ashwini Davuluri | United States of America (the) | Florida | Jacksonville |
| 438 | St Johns Ctr Clin Rsch-St. Aug | Ameeth Vedre | United States of America (the) | Florida | St. Augustine |
| 439 | National Heart Institute Cal | Norman Lepor | United States of America (the) | California | Beverly Hills |
| 440 | Lundquist Inst-Biomed Innovtn | Matthew Budoff | United States of America (the) | California | Torrance |
| 441 | Valley Clinical Trials, Inc. | Mehrdad Ariani | United States of America (the) | California | Northridge |
| 442 | Duke University | Marat Fudim | United States of America (the) | North Carolina | Durham |
| 443 | Rama Research LLC | Bhola Rama | United States of America (the) | Ohio | Marion |
| 444 | Henry Ford Hlth System_Detroit | Khaled Abdul-Nour | United States of America (the) | Michigan | Detroit |
| 445 | St Louis Heart & Vascular, P.C. | Harvey Serota | United States of America (the) | Missouri | St. Louis |
| 446 | Pentucket Medical Associates | Sunny Srivastava | United States of America (the) | Massachusetts | Haverhill |
| 447 | University Of Louisville | Dinesh Kalra | United States of America (the) | Kentucky | Louisville |
| 448 | Midwest Heart & Vasc Spec | Theodore Pope | United States of America (the) | Kansas | Overland Park |
| 449 | Cardiovasc Spec of Willowbrook | Aditya Samal | United States of America (the) | Texas | Houston |
| 450 | UTD SW Medical Center-Dallas | Ambarish Pandey | United States of America (the) | Texas | Dallas |
| 451 | Sherman Clinical Research | Nikhil Joshi | United States of America (the) | Texas | Sherman |
| 452 | VA Loma Linda Hlthcr Sys | Ronald Fernando | United States of America (the) | California | Loma Linda |
| 453 | Nature Coast Clin Rsrch_Crystal River | Ranganatha Potu | United States of America (the) | Florida | Crystal River |
| 454 | NSC Research, Inc | Narendra Singh | United States of America (the) | Georgia | Johns Creek |
| 455 | Bridgeport Hospital | Stuart Zarich | United States of America (the) | Connecticut | Bridgeport |
| 456 | NY Presbyt Hosp-W Cornell Med | Parag Goyal | United States of America (the) | New York | New York |
| 457 | Reid Physician Associates | John McGinty | United States of America (the) | Indiana | Richmond |
| 458 | Ascension Saint Agnes Heart Ca | Jesse Doran | United States of America (the) | Maryland | Baltimore |
| 459 | William S Middleton Mem VA Hosp | David Murray | United States of America (the) | Wisconsin | Madison |
| 460 | Johns Hopkins University_Baltimore | Kavita Sharma | United States of America (the) | Maryland | Baltimore |
| 461 | Advanced Cariodvascular LLC | William Davis | United States of America (the) | Alabama | Alexander City |
| 462 | Midwest Cardiovascu Rsrch Foundation | Vijay Mehta | United States of America (the) | Indiana | Elkhart |
| 463 | Texas Heart Inst Medical Ctr | Stephanie Coulter | United States of America (the) | Texas | Houston |
| 464 | Stanford Univ School of Med | Kevin Alexander | United States of America (the) | California | Palo Alto |
| 465 | Saratoga Clinical Research | David Kandath | United States of America (the) | New York | Saratoga Springs |
| 466 | Cardio Partners Clin Res Inst | Neerav Shah | United States of America (the) | Florida | Wellington |
| 467 | Harlem Cardiology_Madison ave | Henock Saint-Jacques | United States of America (the) | New York | New York |
| 468 | Monument Health Clinical Rsrch | Alexander Schabauer | United States of America (the) | South Dakota | Rapid City |
| 469 | Cardiovascular Rsrch of NW_IN | Ravi Bhagwat | United States of America (the) | Indiana | Munster |
| 470 | Purushotham & Akther Kotha MD, inc. | Purushotham Kotha | United States of America (the) | California | La Mesa |
| 471 | Heart Clinic of Hammond | Ghiath Mikdadi | United States of America (the) | Louisiana | Hammond |
| 472 | Minneapolis VA Health Care Sys | Scott Hubers | United States of America (the) | Minnesota | Minneapolis |
| 473 | Ocala Cardiovascular Research | Lan Luo | United States of America (the) | Florida | Ocala |
| 474 | Selma Medical Associates | Philip O'Donnell | United States of America (the) | Virginia | Winchester |
| 475 | Baptist Health Louisville | Steven Heatherly | United States of America (the) | Kentucky | Louisville |
| 476 | Chear Center LLC | David Bernard | United States of America (the) | New York | Bronx |
| 477 | Saint Michael's Med Ctr NJ | Abbas Shehadeh | United States of America (the) | New Jersey | Newark |
| 478 | The Jackson Clinic, PA | Christopher Cherry | United States of America (the) | Tennessee | Jackson |
| 479 | Apex Research Foundation, LLC | Mohsin Alhaddad | United States of America (the) | Tennessee | Jackson |
| 480 | GA Arrhythmia Cons & Rsch Inst | Felix Sogade | United States of America (the) | Georgia | Macon |
| 481 | The Valley Hosptial | Kariann Abbate | United States of America (the) | New Jersey | Ridgewood |
| 482 | York Clinical Research LLC | Charles Lovell | United States of America (the) | Virginia | Norfolk |
| 483 | Morehouse School of Medicine | Anekwe Onwuanyi | United States of America (the) | Georgia | Atlanta |
| 484 | Baptist Health_Elizabethtown | Prabodh Mehta | United States of America (the) | Kentucky | Elizabethtown |
| 485 | Duke University/Southeastern | William Herzog | United States of America (the) | North Carolina | Lumberton |
| 486 | Cardiolg Assoc Rsch LLC_Tupelo | Barry Dean Bertolet | United States of America (the) | Mississippi | Tupelo |
| 487 | Pioneer Clinical Studies | Bernard Ashby | United States of America (the) | Florida | Miami |
| 488 | Chicago Medical Research LLC | Suhail Khadra | United States of America (the) | Illinois | Hazel Crest |
| 489 | Heart Center Rsrch_Hunstville | Walter Herbert Haught | United States of America (the) | Alabama | Huntsville |
| 490 | Northwest Heart Clinical Research, LLC | Steven Lupovitch | United States of America (the) | Illinois | Arlington Heights |
| 491 | Fairview Health Services | Les Forgosh | United States of America (the) | Minnesota | Maplewood |
| 492 | Franciscan Network-IN Heart PHY | Vijay Rao | United States of America (the) | Indiana | Indianapolis |
| 493 | Medication Mgmnt, LLC_Grnsboro | Jagadeesh Ganji | United States of America (the) | North Carolina | Greensboro |
| 494 | Amavita Clinical Research LLC | Pedro Martinez Clark | United States of America (the) | Florida | North Miami Beach |
| 495 | InvivoCure | Rodney Samaan | United States of America (the) | California | Van Nuys |
| 496 | Laurelton Heart Specialist PC | Olakunle Akinboboye | United States of America (the) | New York | Rosedale |
| 497 | Capital Cardiology Associates_Albany | Eugene Pashkovetsky | United States of America (the) | New York | Albany |
| 498 | Asha Clinical Rsch-Munster, LLC | Mohan Kesani | United States of America (the) | Indiana | Hammond |
| 499 | Elite Research Center | Jamal Hammoud | United States of America (the) | Michigan | Flint |
| 500 | UNC Rex Healthcare | Elizabeth Volz | United States of America (the) | North Carolina | Raleigh |
| 501 | VA Greater Los Angeles Hlthcare System | Nediljka Buljubasic | United States of America (the) | California | Los Angeles |
| 502 | Advocate Good Samaritan | Owais Malick | United States of America (the) | Illinois | Downers Grove |
| 503 | Sanford Health_Sioux Falls | Orvar Jonsson | United States of America (the) | South Dakota | Sioux Falls |
| 504 | San Diego Cardiac Center | Hirsch Mehta | United States of America (the) | California | San Diego |
| 505 | OSF HealthCare_Cardiovasc Inst | Chetan Bhardwaj | United States of America (the) | Illinois | Peoria |
| 506 | Roanoke Heart Institute | John Schmedtje | United States of America (the) | Virginia | Roanoke |
| 507 | Healthy Heart Cardiology | Sandeep Khurana | United States of America (the) | Michigan | Grand Rapids |
| 508 | Valley Clinical Trials | Fahed Bitar | United States of America (the) | California | Covina |
| 509 | WVU Heart & Vascular Institute | Kevin Felpel | United States of America (the) | West Virginia | Morgantown |
| 510 | Aultman Hospital | Ataul Qureshi | United States of America (the) | Ohio | Canton |
| 511 | Jacksonville Ctr For Clin Res | Michael Koren | United States of America (the) | Florida | Jacksonville |
| 512 | University of Vermont Medical Center | Peter VanBuren | United States of America (the) | Vermont | Burlington |
| 513 | UCI Health | Dawn Lombardo | United States of America (the) | California | Orange |
| 514 | Audie L. Murphy VA Hospital | Devjit Tripathy | United States of America (the) | Texas | San Antonio |
| 515 | NCH Research Institute | Viviana Navas | United States of America (the) | Florida | Naples |
| 516 | Winter Haven Hospital - BayCare Hlth Sys | Kollagunta Chandrasekhar | United States of America (the) | Florida | Winter Haven |
| 517 | University of Virginia | Antonio Abbate | United States of America (the) | Virginia | Charlottesville |
| 518 | Methodist Medical_Center of Illinois | Alexander Adler | United States of America (the) | Illinois | Peoria |
| 519 | Aurora St. Luke's Medical Centr | Adam Schuldt | United States of America (the) | Wisconsin | Milwaukee |
| 520 | North America Research Institute | Aamir Jamal | United States of America (the) | California | San Dimas |
| 521 | Cambridge Medical Trials | Naseem Jaffrani | United States of America (the) | Louisiana | Alexandria |
| 522 | Logan Health Research | Eve Gillespie | United States of America (the) | Montana | Kalispell |
| 523 | Swedish Medical Center_Seattle | John Petersen | United States of America (the) | Washington | Seattle |
| 524 | NJ Heart | Jasjit Walia | United States of America (the) | New Jersey | Linden |
| 525 | Mount Sinai Hosp at NYC | Johanna Contreras | United States of America (the) | New York | New York |
| 526 | Carient Heart and Vascular | Hamid Taheri | United States of America (the) | Virginia | Manassas |
| 527 | Sentara Clinical Research | Amin Yehya | United States of America (the) | Virginia | Nolfolk |
| 528 | Tennova Healthcare-Turkey Creek Medical Center | Malcolm Foster | United States of America (the) | Tennessee | Knoxville |
| 529 | Clinical Advancement Ctr, PLLC | Pablo Pergola | United States of America (the) | Texas | San Antonio |
| 530 | VA Medical Center_Salem | Ali Iranmanesh | United States of America (the) | Virginia | Salem |
| 531 | David Turbay, MD, PLLC | David Turbay | United States of America (the) | Texas | El Paso |
| 532 | LA State Univ. Hlth Sciences Ctr | Frank Smart | United States of America (the) | Louisiana | New Orleans |
| 533 | Univ. of Nebraska Medical Center_Omaha | Ronald Zolty | United States of America (the) | Nebraska | Omaha |
| 534 | Capitol Cardiology Assoc_Lanham | Vineet Venugopal | United States of America (the) | Maryland | Lanham |
| 535 | Memorial Region Hosp_Hollywood | Priyanka Gosain | United States of America (the) | Florida | Hollywood |
| 536 | Penn State Hershey Medical Center | John Boehmer | United States of America (the) | Pennsylvania | Hershey |
| 537 | Marian David, MD, PC | Marian David | United States of America (the) | New York | Kew Gardens |
| 538 | Cardiology Associates of Fairfield County | Thomas Nero | United States of America (the) | Connecticut | Stamford |
| 539 | Providence Med Research Ctr | Kavisha Singh | United States of America (the) | Washington | Spokane |
| 540 | Banner University Medical Ctr | Radha Gopalan | United States of America (the) | Arizona | Phoenix |
| 541 | University Of Iowa Hospitals and Clinics | Shareef Mansour | United States of America (the) | Iowa | Iowa City |
| 542 | Allegheny Health Network | Hayah Kassis-George | United States of America (the) | Pennsylvania | Pittsburgh |
| 543 | Penn State Hlth Holy Spirit Med Ctr | Andreas Wali | United States of America (the) | Pennsylvania | Camp Hill |
| 544 | James River Cardiology | Shaival Kapadia | United States of America (the) | Virginia | Chesterfield |
| 545 | Penn State Health-Berks Cardiology | David Zisa | United States of America (the) | Pennsylvania | Wyomissing |
| 546 | University of Michigan Medicine | Salim Hayek | United States of America (the) | Michigan | Ann Arbor |
| 547 | Thomas Jefferson University_Philadelphia | Steven Nagelberg | United States of America (the) | Pennsylvania | Philadelphia |
| 548 | Texas Institute of Cardiology PA | Faisal Wahid | United States of America (the) | Texas | McKinney |
| 549 | Loema Med e Bem Estar Centro Especializado em Cardiologia | Maria Helena Vidotti | Brazil | Sao Paulo | Campinas |
| 550 | CIP Centro Integrado de Pesquisas do Hospital de Base | Lilia Maia | Brazil | Sao Paulo | Sao Jose do Rio Preto |
| 551 | Instituto de Pesquisa Clínica de Campinas | Jose Saraiva | Brazil | Sao Paulo | Campinas |
| 552 | PUCCAMP - Hospital e Maternidade Celso Pierro | Aloisio Marchi da Rocha | Brazil | Sao Paulo | Campinas |
| 553 | Hospital Mae de Deus - Porto Alegre | Euler Roberto Fernandes Manenti | Brazil | NA | Porto Alegre/RS |
| 554 | Hospital de Clínicas da Universidade Federal de Goiania | Aguinaldo Figueiredo Freitas Junior | Brazil | NA | Goiania/GO |
| 555 | Hospital Sao Lucas Copacabana | Bruno Paolino | Brazil | Rio de Janeiro | Rio de Janeiro |
| 556 | Nucleo de Pesquisa Clinica do Hospital Vera Cruz | Fernando Carvalho Neuenschwander | Brazil | NA | Belo Horizonte/MG |
| 557 | Hospital de Clínicas de Porto Alegre | Adamastor Pereira | Brazil | Rio Grande do Sul | Porto Alegre |
| 558 | Integral Pesquisa e Ensino | Mauro Esteves Hernandes | Brazil | Sao Paulo | Cidade Nova Votuporanga |
| 559 | ICM - Instituto do Coracao de Marília | Raphael Barreto da Silva | Brazil | NA | Marília/SP |
| 560 | Centro de Diag. e Pesquisa da Osteoporose do Espirito Santo | Fernando Gomes | Brazil | Espirito Santo | Vitoria |
| 561 | CCIH-Consultoria em Controle de Infeccao Hospitalar Ltda | Flavio Giorgeto | Brazil | Minas Gerais | Belo Horizonte |
| 562 | JMF CLINICA DO CORACAO LTDA | Fabio Silveira | Brazil | NA | Aracaju |
| 563 | CardiovidCentro Cardiovascular Colono ClinicaSantaMariambia | Carlos Martinez Cano | Colombia | NA | Medellin |
| 564 | IPS Centro Cientifico Asistencial Jose Luis Accini SAS | Jose Accini Mendoza | Colombia | Atlantico | barranquilla |
| 565 | IPS medicos Internistas de Caldas S.A.S. | Dora Molina de Salazar | Colombia | Caldas | Manizales |
| 566 | Promotora Medica Las Americas S.A. | Juan Polanco Cabrera | Colombia | NA | Medellin |
| 567 | Rodrigo Botero S.A.S | Rodrigo Botero Lopez | Colombia | Antioquia | Medellin |
| 568 | Fundacion Hospital Universidad del Norte | Eder Hernandez Ruiz | Colombia | Barranquilla | Soledad |
| 569 | Clinica de la Costa | Alberto Cadena Bonfanti | Colombia | NA | barranquilla |
| 570 | Corazon IPS S.A.S | Melissa Reyes Diaz | Colombia | NA | barranquilla |
| 571 | Fundacion del Caribe para la Investigacion Biomedica-BIOS | Miguel Urina Triana | Colombia | NA | barranquilla |
| 572 | Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia | Luis Eduardo Echeverria Correa | Colombia | Santander | BUCARAMANGA-PIEDECUESTA, Valle del Menzuli - SANTANDER |
| 573 | Hospital General de Medellin | Mauricio Quintero Betancur | Colombia | Antioquia | Medellin |
| 574 | Centro Medico Imbanaco | Alvaro Herrera Escandon | Colombia | NA | Cali |
| 575 | Centro de atencionoe investigacion cardiovascular del Potosi | Jose Arenas Leon | Mexico | San Luis Potosi | San Luis Potosi |
| 576 | Diseno y Planeacion en Investigacion Medica S.C. | Cesar Calvo Vargas | Mexico | Jalisco | Guadalajara |
| 577 | Cardiolink Clin Trials S.C. | Elias Garcia Cantu | Mexico | Nuevo Leon | Monterrey |
| 578 | Centro para el Desarrollo de la Medicina y la Asistencia | Manuel de los Rios Ibarra | Mexico | Sinaloa | Culiacan |
| 579 | Centro de Estudios Clinicos de Queretaro S.C. | Marco Alcocer Gamba | Mexico | Queretaro | Santiago de Queretaro, Qro. |
| 580 | Internal Medicine Clin Trials | Jose Garza Ruiz | Mexico | Nuevo Leon | Monterrey |
| 581 | Hospital Cardiologica Aguascalientes | Guillermo Llamas Esperon | Mexico | Ags | Aguascalientes |
| 582 | Instituto Nacional de Cardiologia Ignacio Chavez | Amada Alvarez Sangabriel | Mexico | Mexico, D.F. | Ciudad de Mexico |
| 583 | Eukarya Pharmasite S.C. | Herminio Lopez Zertuche | Mexico | Nuevo Leon | Monterrey |
| 584 | Hospital Angeles de Xalapa | Gustavo Mendez Machado | Mexico | Veracruz | Xalapa |
| 585 | CINCAME | Pedro Fajardo Campos | Mexico | Baja California | Tijuana |
| 586 | Centro de Investigación y Control Metabolico S. C. | Victor Castelan Vargas | Mexico | NL | San Nicolas de los Garza |
| 587 | Centro de Investigacion Biomedica y Farmaceutica S.C. | Manuel Aguilera Real | Mexico | NA | Mexico city |
| 588 | Medizinische Universitat Graz | Dirk von Lewinski | Austria | NA | Graz |
| 589 | Imed 19- privat | Christopher Adlbrecht | Austria | NA | Wien |
| 590 | Klinik Favoriten | Diana Bonderman | Austria | NA | Wien |
| 591 | Krankenhaus St. Josef Braunau | Johann Auer | Austria | NA | Braunau |
| 592 | Medizinische Universitat Wien | Jutta Bergler-Klein | Austria | NA | Vienna |
| 593 | Flieber-Gorzer [Ordination] | Evelyn Flieber-Gorzer | Austria | NA | St. Stefan |
| 594 | Klinik Ottakring | Kurt Huber | Austria | NA | Vienna |
| 595 | UZA - UZ Antwerpen - Cardiology Department | Constantijn Franssen | Belgium | NA | Edegem |
| 596 | AZ Groeninge - Kortrijk - Cardiology | David Derthoo | Belgium | NA | Kortrijk |
| 597 | Ziekenhuis Oost-Limburg AV - Cardiology | Wilfried Mullens | Belgium | NA | Genk |
| 598 | CHR de la Citadelle | Julien Tridetti | Belgium | NA | Liege |
| 599 | UZ Brussel | Frederik Verbrugge | Belgium | NA | Brussel |
| 600 | OLV Ziekenhuis Aalst-Asse-Ninove | Riet Dierckx | Belgium | NA | Aalst |
| 601 | Centre Hospitalier Universitaire De Montpellier | Francois ROUBILLE | France | NA | Montpellier |
| 602 | APHP - Hopital La Pitie Salpetriere | Richard ISNARD | France | NA | PARIS |
| 603 | CHU de Toulouse - Hopital Rangueil | Michel GALINIER | France | NA | toulouse |
| 604 | APHP - Hopital Lariboisiere | Damien LOGEART | France | NA | PARIS |
| 605 | Centre Hospitalier Universitaire de Poitiers | Claire BOULETI | France | NA | POITIERS |
| 606 | CHU de Grenoble - Alpes | Muriel SALVAT | France | NA | LA TRONCHE |
| 607 | The Heartbeat Trust | Kenneth McDonald | Ireland | NA | Dublin |
| 608 | Mater Private Network - Dublin | Robert Byrne | Ireland | NA | Dublin |
| 609 | Mater Miscericordiae Hospital | Niall Mahon | Ireland | NA | Dublin |
| 610 | Mater Private Network Cork | James Dollard | Ireland | NA | Mahon, Cork |
| 611 | Rikshospitalet - Kardiologisk forskning | Kaspar Broch | Norway | NA | Oslo |
| 612 | Haukeland Universitetssykehus | Gaute Vollan | Norway | NA | Bergen |
| 613 | Akershus universitetssykehus HF | Peder Langeland Myhre | Norway | NA | Lorenskog |
| 614 | Stavanger Universitetssykehus, Helse Stavanger HF | Noreen Butt | Norway | NA | STAVANGER |
| 615 | Oslo universitetssykehus HF - Ulleval | Sigrun Halvorsen | Norway | NA | Oslo |
| 616 | St. Richards Hospital | Yuk-ki Wong | United Kingdom of Great Britain and Northern Ireland (the) | West Sussex | Chichester |
| 617 | Glasgow Clinical Research Facility | Mark Petrie | United Kingdom of Great Britain and Northern Ireland (the) | NA | Glasgow |
| 618 | Manchester Royal Infirmary_Manchester_0 | Fozia Ahmed | United Kingdom of Great Britain and Northern Ireland (the) | NA | Manchester |
| 619 | University Hospital Aintree | Prathap Kanagala | United Kingdom of Great Britain and Northern Ireland (the) | NA | Liverpool |
| 620 | St George's Hospital | Robin Ray | United Kingdom of Great Britain and Northern Ireland (the) | London | Tooting |
| 621 | Craigavon Area Hospital | Patricia Campbell | United Kingdom of Great Britain and Northern Ireland (the) | NA | Craigavon |
| 622 | Royal Bournemouth Hospital | Chris Critoph | United Kingdom of Great Britain and Northern Ireland (the) | NA | Dorest |
| 623 | University of North Tees Hospital | Matthew Dewhurst | United Kingdom of Great Britain and Northern Ireland (the) | NA | Stockton-on-Tees |
| 624 | John Radcliffe Hospital | James Gamble | United Kingdom of Great Britain and Northern Ireland (the) | NA | Oxford |
| 625 | North Tyneside General Hospital | Thomas Green | United Kingdom of Great Britain and Northern Ireland (the) | NA | North Shields |
| 626 | Aberdeen Royal Infirmary | Vera Lennie | United Kingdom of Great Britain and Northern Ireland (the) | NA | Aberdeen |
| 627 | Royal Devon University Healthcare NHS Foundation Trust | Andrew Ludman | United Kingdom of Great Britain and Northern Ireland (the) | NA | Exeter |
| 628 | University Hospital Monklands | Colin Petrie | United Kingdom of Great Britain and Northern Ireland (the) | Lanarkshire | Airdrie |
| 629 | Basildon University Hospital | Henry Savage | United Kingdom of Great Britain and Northern Ireland (the) | Essex | Basildon |
| 630 | Wycombe General Hospital | Mayooran Shanmuganathan | United Kingdom of Great Britain and Northern Ireland (the) | NA | High Wycombe |
| 631 | University Hospital Hairmyres | Robin Weir | United Kingdom of Great Britain and Northern Ireland (the) | South Lanarkshire | East Kilbride |
| 632 | Southmead Hospital | Chih Wong | United Kingdom of Great Britain and Northern Ireland (the) | NA | Bristol |
| 633 | North Estonia Medical Centre Foundation | Riina Vettus | Estonia | NA | Tallinn |
| 634 | East Tallinn Central Hospital | Henri Kaljumae | Estonia | NA | Tallinn |
| 635 | Tartu University Hospital | Eve Laane | Estonia | NA | Tartu |
| 636 | PHI City General Hospital 8th September | Antonio Antovski | North Macedonia | Skopje | Skopje |
| 637 | PHI University Clinic for Cardiology | Oliver Bushljetikj | North Macedonia | Skopje | Skopje |
| 638 | Clinical Centre of Serbia, Emergency Centre, Department of Cardiology | Goran Stankovic | Serbia | Serbia | Belgrade |
| 639 | Institute for Cardiovascular Diseases Dedinje | Petar Otasevic | Serbia | NA | Belgrade |
| 640 | Clinical centre of Serbia, Clinic for cardiology | Arsen Ristic | Serbia | Serbia | Belgrade |
| 641 | Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica | Mila Kovacevic | Serbia | NA | Sremska Kamenica |
| 642 | Clinical Hospital Centre Zemun | Aleksandar Neskovic | Serbia | Serbia | Belgrade |
| 643 | University Clinical Centre Nis, Clinic for Cardiology | Goran Koracevic | Serbia | Serbia | Nis |
| 644 | Clinical Centre of Serbia, Emergency Centre, Department of Cardiology | Milika Asanin | Serbia | Serbia | Belgrade |
| 645 | Emergency Internal Medicine Clinic | Slobodan Obradovic | Serbia | NA | Belgrade |
| 646 | Clinical Hospital Center Bezanijska Kosa | Marija Zdravkovic | Serbia | NA | Belgrade |
| 647 | University Clinical Centre Kragujevac | Vladimir Zdravkovic | Serbia | NA | Kragujevac |
| 648 | UKC Ljubljana, Cardiology department | Bojan Vrtovec | Slovenia | NA | Ljubljana |
| 649 | UKC Maribor - cardiology | Franjo Naji | Slovenia | NA | Maribor |
| 650 | General hospital Celje - cardiology | Dragan Kovacic | Slovenia | NA | Celje |
| 651 | Afyonkarahisar Health Sciences University | Ugur Aksu | Turkiye | NA | Afyon |
| 652 | Dokuz Eylul University School of Medicine, Cardiology | Mehmet Yilmaz | Turkiye | NA | Izmir |
| 653 | Hacettepe University Medical Faculty_Ankara | Lale Tokgozoglu | Turkiye | NA | Ankara |
| 654 | Dr. Siyami Ersek Gogus Kalp ve Damar Cerrahisi EAH | Baris Gungor | Turkiye | NA | Istanbul |
| 655 | Akdeniz University Medical Faculty | Murathan Kucuk | Turkiye | NA | ANTALYA |
| 656 | Eskisehir Osmangazi University-Cardio | Yuksel Cavusoglu | Turkiye | NA | Eskisehir |
| 657 | Erciyes University Cardiology | Abdurrahman Oguzhan | Turkiye | NA | Kayseri |
| 658 | Kocaeli Universitesi Tip Fakultesi Hastanesi | Tayfun Sahin | Turkiye | NA | Kocaeli |
| 659 | Ege University School of Medicine, Cardiology Department | Sanem Nalbantgil | Turkiye | NA | Izmir |
| 660 | Mersin University Cardiology | Ahmet Celik | Turkiye | NA | Mersin |
| 661 | Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training Research Hospital_Istanbul | Omer Celik | Turkiye | NA | Istanbul |
| 662 | Trakya University | Servet Altay | Turkiye | NA | Edirne |
| 663 | Taipei Veterans General Hospital | Chern-En Chiang | 中国台湾 | NA | Taipei |
五、伦理委员会信息
| 序号 | 名称 | 审查结论 | 批准日期/备案日期 |
|---|---|---|---|
| 1 | 北京安贞医院临床研究伦理委员会 | 同意 | 2023-03-06 |
| 2 | 北京安贞医院临床研究伦理委员会 | 同意 | 2023-05-26 |
六、试验状态信息
1、试验状态
进行中 （招募中）
2、试验人数
| 目标入组人数 | 国内: 254 ； 国际: 5600 ； |
|---|---|
| 已入组人数 | 国内: 1 ； 国际: 560 ； |
| 实际入组总人数 | 国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息； |
3、受试者招募及试验完成日期
| 第一例受试者签署知情同意书日期 | 国内：2023-11-20； 国际：2023-05-08； |
|---|---|
| 第一例受试者入组日期 | 国内：2023-11-29； 国际：2023-05-17； |
| 试验完成日期 | 国内：登记人暂未填写该信息； 国际：登记人暂未填写该信息； |
七、临床试验结果摘要
| 序号 | 版本号 | 版本日期 |
|---|---|---|
| 暂未填写此信息 | ||
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