基本信息
| 登记号 | CTR20220172 | 试验状态 | 进行中 |
|---|---|---|---|
| 申请人联系人 | 郭艳芳 | 首次公示信息日期 | 2022-01-26 |
| 申请人名称 | Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc./ 默沙东研发（中国）有限公司/ Bayer AG/ Fisher Clinical Services GmbH | ||
公示的试验信息
一、题目和背景信息
| 登记号 | CTR20220172 | ||
|---|---|---|---|
| 相关登记号 | |||
| 药物名称 | Vericiguat片 | ||
| 药物类型 | 化学药物 | ||
| 临床申请受理号 | 企业选择不公示 | ||
| 适应症 | 慢性射血分数降低型心力衰竭（HFrEF） | ||
| 试验专业题目 | 一项在射血分数降低型慢性心力衰竭成人患者中评价sGC刺激剂vericiguat/MK-1242有效性和安全性的关键性、III期、随机、安慰剂对照临床研究 | ||
| 试验通俗题目 | Vericiguat治疗HFrEF的结局研究 | ||
| 试验方案编号 | 035-00 | 方案最新版本号 | 02 |
| 版本日期: | 2022-08-01 | 方案是否为联合用药 | 否 |
二、申请人信息
| 申请人名称 | 1 2 3 4 | ||||
|---|---|---|---|---|---|
| 联系人姓名 | 郭艳芳 | 联系人座机 | 010-58609033 | 联系人手机号 | |
| 联系人Email | yanfang.guo@merck.com | 联系人邮政地址 | 北京市-北京市-朝阳区容达路21号楼L2 | 联系人邮编 | 100012 |
三、临床试验信息
1、试验目的
1. 评价vericiguat与安慰剂相比降低心血管死亡或心力衰竭住院风险的有效性；2. 评价vericiguat与安慰剂相比降低心血管死亡风险的有效性；3. 评价vericiguat与安慰剂相比降低心力衰竭住院风险的有效性；4. 评价vericiguat与安慰剂相比降低全因死亡或心力衰竭住院风险的有效性；5. 评价vericiguat与安慰剂相比降低全因死亡风险的有效性；6. 评价vericiguat与安慰剂相比的安全性和耐受性。
2、试验设计
| 试验分类 | 安全性和有效性 | 试验分期 | III期 | 设计类型 | 平行分组 |
|---|---|---|---|---|---|
| 随机化 | 随机化 | 盲法 | 双盲 | 试验范围 | 国际多中心试验 |
3、受试者信息
| 年龄 | 18岁(最小年龄)至 无上限 (最大年龄) | ||
|---|---|---|---|
| 性别 | 男+女 | ||
| 健康受试者 | 无 | ||
| 入选标准 | 1 有慢性HF（NYHA II-IV级）病史，并接受指南推荐的心力衰竭药物治疗（GDMT），在随机分组前6个月内未发生HFH事件，且在随机分组前3个月内未使用门诊静脉利尿剂。 2 男性或女性，签署书面知情同意时年龄至少为18岁。 3 女性受试者无妊娠或哺乳，且至少符合以下条件之一，则有资格参加： * 不是具有生育能力的女性（WOCBP） 或 * 是WOCBP，但如附录5所述，在研究干预期间以及末次研究干预之后至少一月内，采用使用者依赖程度低的高效（年避孕失败率<1%）的避孕方法，或禁止异性性行为作为其首选的日常生活方式（长期持续禁欲）。研究者应评估与研究干预首次给药相关的避孕方法失败（即不依从、近期开始）的可能性。 -WOCBP在研究干预首次给药前24小时内的高灵敏度妊娠试验（当地法规要求的尿液或血清）结果必须为阴性。 -如果不能确认尿液妊娠试验为阴性（例如，结果不明确），则需要进行血清妊娠试验。在这种情况下，如果血清妊娠结果为阳性，则必须将受试者从研究中排除。 -研究干预期间和干预结束后对妊娠试验的其他要求见第8.3.6节 -研究者负责审查病史、月经史和近期性生活史，从而降低入选未检测出的早期妊娠女性的风险。 -女性受试者使用的避孕措施应符合当地关于临床研究受试者避孕方法的法规。 4 受试者（或法定监护人）已签署研究知情同意书。受试者还可提供未来生物医学研究（FBR）的同意/赞同。但是，受试者可以不参加FBR，只参加本研究。 5 如表1所示，在随机化前30天内有符合筛选要求水平的NT-proBNP结果。对于筛选期间具有多个NT-proBNP结果的受试者，将在随机访视时使用最新的结果数值确定受试者的入选资格。（NT-proBNP入选标准表，详见临床试验方案表1） 6 随机分组前12个月内通过任何影像学方法评估的LVEF ≤40%。必须使用最新的测量值确定受试者的入选资格。 注：接受可能改善LVEF的冠状动脉血运重建（PCI或CABG）、瓣膜修复/置换或CRT器械植入或任何其他外科、器械或药物干预（即开始使用一种GDMT）的受试者必须在干预至少3个月后测量LVEF后确认入选资格。 | ||
| 排除标准 | 1 SBP < 100 mmHg或患有症状性低血压。 2 已知对vericiguat、其任何成分或任何其他sGC刺激剂过敏或敏感。 3 正在等待心脏移植（美国器官资源共享网络1A/1B级或同等情况），或正在接受正性肌力药连续IV输注，或已经或计划植入心室辅助装置。 4 患有淀粉样变性或肉状瘤病。 5 患有需要外科手术或介入治疗的心脏瓣膜病，或在随机分组前3个月内接受过瓣膜外科手术或介入治疗。 6 患有肥厚性心肌病。 7 患有急性心肌炎或Takotsubo心肌病 8 接受过心脏移植。 9 患有心动过速引发的心肌病和/或无法控制的快速性心律失常。 10 在随机分组前3个月内发生过急性冠脉综合征（不稳定型心绞痛、NSTEMI或STEMI），接受过CABG或PCI，或在随机分组时有冠状动脉血运重建的指征。 11 随机分组前3个月内发生过症状性颈动脉狭窄、TIA（短暂性脑缺血发作）或卒中。 12 已修复或未修复的单纯性先天性心脏病（例如，房间隔缺损或室间隔缺损或动脉导管未闭）病史伴持续血流动力学显著残留病变，或患有任何复杂性先天性心脏病病史（例如，法洛四联症、大动脉转位、单心室疾病），无论是否已修复。 13 患有活动性心内膜炎或缩窄性心包炎。 14 随机分组前30天内，基于CKD-EPI肌酐方程计算得出的eGFR < 15 mL/min/1.73 m2或正在接受长期透析。对于筛选期间具有多个eGFR结果的受试者，将在随机分组访视时使用最新的数值确定入选资格。 15 患有定义为ALBI 3级或肝性脑病的重度肝功能不全，或者存在肝脏实验室检查异常（ALT或AST ≥ 3×ULN或总胆红素 ≥2×ULN）。随机分组前30天内的白蛋白、ALT、AST和总胆红素筛选结果可用于评估实验室异常或计算ALBI评分。对于筛选期间有多项白蛋白和/或总胆红素结果的受试者，将使用每项检查的最新值计算ALBI评分，如附录8[Fragaki, M., et al 2019]所定义。 16 患有导致预期寿命 < 3年的恶性肿瘤或其他非心脏疾病。 17 患有重度肺病（需要持续家庭供氧）。 18 患有间质性肺病。 19 随机分组前4周内停用或调整GDMT（包括β受体阻滞剂、ACEI/ARB、ARNI、MRA、肼苯哒嗪-硝酸盐复方制剂、SGLT2抑制剂或伊伐布雷定）或vericiguat的剂量。 20 研究期间合并或预期合并使用PDE5抑制剂，如伐地那非、他达拉非和西地那非。 21 同时使用sGC刺激剂，如利奥西呱或vericiguat。 22 在随机分组前30天内参加过另一项干预性临床研究或接受过另一种试验用药品治疗，或计划在本研究期间参加任何其他研究或研究干预。 23 近期（过去一年内）有药物或酒精滥用或依赖史。 24 妊娠或哺乳，或计划在研究期间妊娠或哺乳。 25 患有研究者认为会损害受试者参加或完成研究能力的疾病、状况或病史。 26 本人是或有直系亲属（如配偶、父母/法定监护人、兄弟姐妹或子女）是直接参与本研究的研究中心或申办方工作人员。 | ||
4、试验分组
| 试验药 | 序号 名称 用法 1 中文通用名:Vericiguat片 英文通用名:Vericiguat Tablets 商品名称:NA 剂型:片剂 规格:2.5 mg 用法用量:试验组将接受Vericiguat片剂给药，起始剂量2.5 mg 口服，每日一次。 用药时程:整体疗程为第1天至治疗结束，具体剂量使用时长依据滴定方案和受试者耐受性。 2 中文通用名:Vericiguat片 英文通用名:Vericiguat Tablets 商品名称:NA 剂型:片剂 规格:5 mg 用法用量:试验组在接受Vericiguat起始剂量后，按照滴定方案和受试者耐受性，首次上调至5 mg 口服，每日一次。 用药时程:整体疗程为第1天至治疗结束，具体剂量使用时长依据滴定方案和受试者耐受性。 3 中文通用名:Vericiguat片 英文通用名:Vericiguat Tablets 商品名称:NA 剂型:片剂 规格:10 mg 用法用量:试验组在接受Vericiguat首次上调剂量后，按照滴定方案和受试者耐受性，第二次上调至10 mg（目标剂量） 口服，每日一次。 用药时程:整体疗程为第1天至治疗结束，具体剂量使用时长依据滴定方案和受试者耐受性。 |
|---|---|
| 对照药 | 序号 名称 用法 1 中文通用名:安慰剂 英文通用名:Placebo 商品名称:NA 剂型:片剂 规格:0 mg 用法用量:对照组给予匹配的安慰剂，口服，每日一次。 用药时程:第1天至治疗结束 2 中文通用名:安慰剂 英文通用名:Placebo 商品名称:NA 剂型:片剂 规格:0 mg 用法用量:对照组给予匹配的安慰剂，口服，每日一次。 用药时程:第1天至治疗结束 |
5、终点指标
| 主要终点指标及评价时间 | 序号 指标 评价时间 终点指标选择 1 从随机分组至首次发生心血管死亡或心力衰竭住院事件的时间 研究达到预期数量的主要终点事件和CV死亡事件时 有效性指标 |
|---|---|
| 次要终点指标及评价时间 | 序号 指标 评价时间 终点指标选择 1 从随机分组至心血管死亡的时间 研究达到预期数量的主要终点事件和CV死亡事件时 有效性指标 2 从随机分组至首次发生心力衰竭住院事件的时间； 从随机分组至所有心力衰竭住院事件的时间 研究达到预期数量的主要终点事件和CV死亡事件时 有效性指标 3 从随机分组至首次发生全因死亡或心力衰竭住院事件的时间 研究达到预期数量的主要终点事件和CV死亡事件时 有效性指标 4 从随机分组至全因死亡的时间 研究达到预期数量的主要终点事件和CV死亡事件时 有效性指标 5 选定非严重不良事件 严重不良事件 临床关注事件 完成末次给药后14天的安全性联系时 安全性指标 |
6、数据安全监查委员会（DMC）
有
7、为受试者购买试验伤害保险
有
四、研究者信息
1、主要研究者信息
| 1 | 姓名 | 葛均波 | 学位 | 医学博士 | 职称 | 教授 |
|---|---|---|---|---|---|---|
| 电话 | 021-64041990 | ge.junbo@zs-hospital.sh.cn | 邮政地址 | 上海市-上海市-徐汇区枫林路180号 | ||
| 邮编 | 200032 | 单位名称 | 复旦大学附属中山医院 | |||
2、各参加机构信息
| 序号 | 机构名称 | 主要研究者 | 国家或地区 | 省（州） | 城市 |
|---|---|---|---|---|---|
| 1 | 复旦大学附属中山医院 | 葛均波 ; 周京敏 | 中国 | 上海市 | 上海市 |
| 2 | 广东省人民医院 | 陈纪言 | 中国 | 广东省 | 广州市 |
| 3 | 陕西省人民医院 | 王军奎 | 中国 | 陕西省 | 西安市 |
| 4 | 长沙市中心医院 | 蒋路平 | 中国 | 湖南省 | 长沙市 |
| 5 | 上海交通大学医学院附属瑞金医院 | 金玮 | 中国 | 上海市 | 上海市 |
| 6 | 首都医科大学附属北京安贞医院 | 董建增 | 中国 | 北京市 | 北京市 |
| 7 | 湖南省人民医院 | 彭建强 | 中国 | 湖南省 | 长沙市 |
| 8 | 辽宁省人民医院 | 李占全 | 中国 | 辽宁省 | 沈阳市 |
| 9 | 中南大学湘雅三医院 | 蒋卫红 | 中国 | 湖南省 | 长沙市 |
| 10 | 苏北人民医院 | 顾翔 | 中国 | 江苏省 | 扬州市 |
| 11 | 丽水市人民医院 | 梅益斌 | 中国 | 浙江省 | 丽水市 |
| 12 | 兰州大学第二医院 | 余静 | 中国 | 甘肃省 | 兰州市 |
| 13 | 西安交通大学附属第一医院 | 袁祖贻 | 中国 | 陕西省 | 西安市 |
| 14 | 首都医科大学附属北京友谊医院 | 沈爱东 | 中国 | 北京市 | 北京市 |
| 15 | 包头市中心医院 | 赵瑞平 | 中国 | 内蒙古自治区 | 包头市 |
| 16 | 天津市人民医院 | 姚朱华 | 中国 | 天津市 | 天津市 |
| 17 | 中山大学孙逸仙纪念医院 | 王景峰 | 中国 | 广东省 | 广州市 |
| 18 | 无锡市人民医院 | 羊镇宇 | 中国 | 江苏省 | 无锡市 |
| 19 | 上海市徐汇区中心医院 | 缪培智 | 中国 | 上海市 | 上海市 |
| 20 | 温州医科大学附属第一医院 | 黄周青 | 中国 | 浙江省 | 温州市 |
| 21 | 北京大学人民医院 | 陈红 | 中国 | 北京市 | 北京市 |
| 22 | 上海市杨浦区中心医院 | 王加红 | 中国 | 上海市 | 上海市 |
| 23 | 无锡市第二人民医院 | 徐欣 | 中国 | 江苏省 | 无锡市 |
| 24 | 南京鼓楼医院 | 徐标 | 中国 | 江苏省 | 南京市 |
| 25 | 海南省人民医院 | 乔平 | 中国 | 海南省 | 海口市 |
| 26 | 香港大学深圳医院 | 刘铭雅 | 中国 | 广东省 | 深圳市 |
| 27 | 暨南大学附属第一医院 | 巫少荣 | 中国 | 广东省 | 广州市 |
| 28 | 佛山市第一人民医院 | 梁茜 | 中国 | 广东省 | 佛山市 |
| 29 | 中南大学湘雅医院 | 马琦琳 | 中国 | 湖南省 | 长沙市 |
| 30 | 南京医科大学第二附属医院 | 龙明智 | 中国 | 江苏省 | 南京市 |
| 31 | 天津市胸科医院 | 丛洪良 | 中国 | 天津市 | 天津市 |
| 32 | 天津医科大学第二医院 | 李广平 | 中国 | 天津市 | 天津市 |
| 33 | 哈尔滨医科大学附属第一医院 | 李为民 | 中国 | 黑龙江省 | 哈尔滨市 |
| 34 | 四川大学华西医院 | 张庆 | 中国 | 四川省 | 成都市 |
| 35 | 上海市同济医院 | 赵翠梅 | 中国 | 上海市 | 上海市 |
| 36 | 新疆医科大学第一附属医院 | 艾力曼﹒马合木提 | 中国 | 新疆维吾尔自治区 | 乌鲁木齐市 |
| 37 | 浙江大学附属第一医院 | 胡晓晟 | 中国 | 浙江省 | 杭州市 |
| 38 | 重庆医科大学附属第二医院 | 殷跃辉 | 中国 | 重庆市 | 重庆市 |
| 39 | 浙江大学医学院附属第二医院 | 蒋峻 | 中国 | 浙江省 | 杭州市 |
| 40 | 徐州医科大学附属医院 | 罗园媛 | 中国 | 江苏省 | 徐州市 |
| 41 | 北京清华长庚医院 | 张萍 | 中国 | 北京市 | 北京市 |
| 42 | 南昌大学第二附属医院 | 吴延庆 | 中国 | 江西省 | 南昌市 |
| 43 | 重庆大学附属三峡医院 | 庞小华 | 中国 | 重庆市 | 重庆市 |
| 44 | 浙江省人民医院 | 王利宏 | 中国 | 浙江省 | 杭州市 |
| 45 | 四平市中心人民医院 | 房志华 | 中国 | 吉林省 | 四平市 |
| 46 | 吉林大学中日联谊医院 | 杨萍 | 中国 | 吉林省 | 长春市 |
| 47 | 江苏大学附属医院 | 袁伟 | 中国 | 江苏省 | 镇江市 |
| 48 | 航天中心医院 | 丁春华 | 中国 | 北京市 | 北京市 |
| 49 | 华中科技大学同济医学院附属协和医院 | 黄恺 | 中国 | 湖北省 | 武汉市 |
| 50 | 安徽省立医院 | 马礼坤 | 中国 | 安徽省 | 合肥市 |
| 51 | Apex Research Foundation | Alhaddad,Mohsin | US | TN | Jackson |
| 52 | Louisiana Heart Center - Hammond | Bernstein,Marc | US | LA | HAMMOND |
| 53 | University of Iowa | Cadaret,Linda | US | IA | Iowa City |
| 54 | Valley Clinical Trials, Inc. | Ariani,Mehrdad | US | CA | Northridge |
| 55 | Excel Medical Clinical Trials | FUNT,DAVID | US | FL | Boca Raton |
| 56 | CHEAR Center LLC | Bernard,David Barnett | US | NY | Bronx |
| 57 | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Budoff,Matthew J | US | CA | Torrance |
| 58 | Indago Research & Health Center, Inc | Cardona,Jose Francisco | US | FL | Hialeah |
| 59 | West Houston Area Clinical Trial Consultants | Feldman,James | US | TX | Houston |
| 60 | East Coast Institute for Research - St. Augustine | George,Ferris | US | FL | St. Augustine |
| 61 | Logan Health Research | Gillespie,Eve | US | MT | Kalispell |
| 62 | South Texas Cardiovascular Consultants, PLLC | Isiguzo,Obinna G. | US | TX | San Antonio |
| 63 | Universal Axon Clinical Research, LLC | Martinez,Luis | US | FL | Doral |
| 64 | South Texas Cardiovascular Consultants, PLLC | Melucci,Mike B. | US | TX | Kerrville |
| 65 | St. Louis Heart and Vascular, P.C. | Qayyum,Usman | US | MO | St. Louis |
| 66 | Doylestown Hospital | Sangrigoli,Renee | US | PA | Doylestown |
| 67 | Roanoke Heart Institute PLC | Schmedtje,John Frederick | US | VA | Roanoke |
| 68 | ProLive Medical Research | Suarez,Rosa M | US | FL | Miami |
| 69 | The Valley Hospital - Luckow Pavilion | Williams,Marcus L. | US | NJ | Ridgewood |
| 70 | Cardiovascular Research of Northwest Indiana | Bhagwat,Ravi S. | US | IN | Munster |
| 71 | IMA Clinical Research Warren | Falcone,Robert Stephen | US | NJ | Raritan |
| 72 | Advanced Cardiovascular - Alexander City | Foley,Brian A. | US | AL | Alexander City |
| 73 | Tyler Cardiovascular Consultants | Gangasani,Ashish | US | TX | Tyler |
| 74 | Cambridge Medical Trials | Jaffrani,Naseem | US | LA | Alexandria |
| 75 | Georgia Arrhythmia Consultants and Research Institute | Sogade,Felix O | US | GA | Macon |
| 76 | Medresearch Inc | Vasallo,Javier | US | TX | El Paso |
| 77 | Washington University School of Medicine | Ewald,Gregory Alan | US | MO | Saint Louis |
| 78 | Mercy Research | Young,Vernon | US | MO | Washington |
| 79 | East Coast Institute for Research, LLC | Ashchi,Majdi | US | FL | Jacksonville |
| 80 | Mount Sinai Hospital | Khosla,Sandeep | US | IL | Chicago |
| 81 | Blue Coast Research Center | Bui,Hanh M | US | CA | Vista |
| 82 | Reid Physician Associates | McGinty,John Edward | US | IN | Richmond |
| 83 | Maryland Cardiovascular Specialists | Doran,Jesse A | US | MD | Baltimore |
| 84 | South Florida Research Solutions | Spiller,Dennis | US | FL | Hollywood |
| 85 | Carient Heart & Vascular - Manassas | Taheri,Hamid | US | VA | Manassas |
| 86 | Vanderbilt University Medical Center | Brinkley,Douglas Marshall | US | TN | Nashville |
| 87 | ProMedica Toledo Hospital | Hariri,Imad | US | OH | Toledo |
| 88 | Norton Healthcare | McCants,Kelly | US | KY | Louisville |
| 89 | Aultman Hospital | Qureshi,Ataul | US | OH | Canton |
| 90 | NSC Research | Singh,Narendra | US | GA | Johns Creek |
| 91 | Northwell Health Physician Partners Cardiology - Southampton | Donahoe,Sean M | US | NY | Southampton |
| 92 | Phillips Medical Services | Phillips,Andrea Lynn | US | MS | Jackson |
| 93 | University of Cincinnati Medical Center | VIERECKE,JULIANE KATJA | US | OH | Cincinnati |
| 94 | Cardiovascular Institute of the South | Fail,Peter S. | US | LA | Houma |
| 95 | The University of Mississippi Medical Center | papadimitriou,Lampros | US | MS | Jackson |
| 96 | Miami Cardiac & Vascular Institute-Ambulatory Research | Lloret,Ramon | US | FL | Miami |
| 97 | Mercy Gilbert Medical Center | Dib,Nabil | US | AZ | Gilbert |
| 98 | Marshfield Medical Center - Marshfield | Anderson,Kelley | US | WI | Marshfield |
| 99 | Cardiovascular Institute of the South | Ayalloore,Siby | US | LA | Opelousas |
| 100 | Dallas VA Medical Center | Michelis,Katherine | US | TX | Dallas |
| 101 | Valley Clinical Trials, Inc. | Bitar,Fahed G | US | CA | Covina |
| 102 | Chicago Medical Research | Khadra,Suhail | US | IL | Hazel Crest |
| 103 | Franciscan Physician Network - Indiana Heart Physicians | Chugh,Atul R. | US | IN | Indianapolis |
| 104 | Peace River Cardiovascular Center | Hotchkiss,David | US | FL | Port Charlotte |
| 105 | Dominion Medical Associates, Inc. | Jackson,Richard | US | VA | Richmond |
| 106 | Accellacare - Wilmington | Janik,Matthew James | US | NC | Wilmington |
| 107 | Ascension Providence Hospital | Zughaib,Marcel E. | US | MI | Southfield |
| 108 | Cardiovascular Institute of the South | May,Wade | US | LA | Lafayette |
| 109 | Cardiovascular Associates of the Delaware Valley | Viswanath,Dilip B. | US | NJ | Washington Township |
| 110 | Methodist Medical Center of Illinois | Adler,Alexander | US | IL | Peoria |
| 111 | BAYCARE MEDICAL GROUP | Nguyen,Van Q | US | FL | Safety Harbor |
| 112 | Holy Cross Hospital | Larned,Joshua M | US | FL | Fort Lauderdale |
| 113 | MultiCare Health System | Everett,John Paul | US | WA | Spokane |
| 114 | Centricity Research Columbus Georgia Multispecialty | Surber,Joseph | US | GA | Columbus |
| 115 | IMA Clinical Research | Napoli,Mark C. | US | LA | Monroe |
| 116 | Sentara Norfolk General Hospital | Old,Wayne | US | VA | Norfolk |
| 117 | Pulse Heart Institute – Puyallup | Malhotra,Vinay | US | WA | Tacoma |
| 118 | University of Arizona Sarver Heart Center | William,Preethi | US | AZ | Tucson |
| 119 | OSF HealthCare Cardiovascular Institute | Sparrow,Christopher Theis | US | IL | Peoria |
| 120 | Emory University School of Medicine | Morris,Alanna A | US | GA | Atlanta |
| 121 | Kernodle Clinic West | Paraschos,Alexander | US | NC | Burlington |
| 122 | New York Presbyterian Medical Group Hudson Valley Cardiology | Hamroff,Glenn | US | NY | Cortland Manor |
| 123 | Southwest Family Medicine Associates | Dharma,Chrisette | US | TX | Dallas |
| 124 | Southeastern Cardiology and Cardiovascular | Walters,Christopher | US | NC | Lumberton |
| 125 | INOVA Fairfax Medical Campus | Isseh,Iyad | US | VA | Falls Church |
| 126 | Cardiovascular Consultants of South Georgia, LLC | Daniels,Christopher L. | US | GA | Thomasville |
| 127 | The Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health | McLean,Dalton S. | US | NC | Greensboro |
| 128 | Ochsner Clinic Foundation | Krim,Selim | US | LA | New Orleans |
| 129 | Accellacare - Charleston | Runquist,Lars H | US | SC | Charleston |
| 130 | Alliance for Multispecialty Research, LLC | Tabbal,Ghiyath | US | KS | Wichita |
| 131 | The Heart Center of Lake County Research Institute | Artis,Andre K. | US | IN | Merrillville |
| 132 | VA West Los Angeles Medical Center | Mody,Freny Vaghaiwalla | US | CA | Los Angeles |
| 133 | University of Alabama at Birmingham - School of Medicine | Arora,Pankaj | US | AL | Birmingham |
| 134 | Cardiovascular Center of Sarasota | El Shahawy,Mahfouz | US | FL | Sarasota |
| 135 | The Heart Clinic - Hammond | Mikdadi,Ghiath | US | LA | Hammond |
| 136 | Heart Center Research, LLC | Velasquez,Enrique Martin | US | AL | Huntsville |
| 137 | Erie County Medical Center | Izzo,Joseph L | US | NY | Buffalo |
| 138 | Icahn School of Medicine at Mount Sinai | Lala-Trindade,Anu | US | NY | New York |
| 139 | University of Missouri Hospital | Bostick,Brian Paul | US | MO | Columbia |
| 140 | Capitol Cardiology Associates - Lanham Office | Venugopal,Vineet | US | MD | Lanham |
| 141 | Renown Regional Medical Center | To,Thomas Duythuc | US | NV | Reno |
| 142 | University of Florida - Jacksonville | Kadariya,Dinesh | US | FL | Jacksonville |
| 143 | Medizinische Universitat Graz | von Lewinski,Dirk | Austria | Steiermark | Graz |
| 144 | Klinik Floridsdorf | Schober,Andreas | Austria | Wien | Vienna |
| 145 | Imed19-privat | Adlbrecht,Christopher | Austria | Wien | Vienna |
| 146 | Krankenhaus St. Josef Braunau | Auer,Johann | Austria | Oberosterreich | Braunau |
| 147 | Uniklinikum Salzburg | Mirna,Moritz | Austria | Salzburg | Salzburg |
| 148 | The Prince Charles Hospital | McKenzie,Scott | Australia | Queensland | Chermside |
| 149 | Core Research Group | Colquhoun,David Martin | Australia | Queensland | Milton |
| 150 | Flinders Medical Centre | De Pasquale,Carmine | Australia | South Australia | Bedford Park |
| 151 | Royal Adelaide Hospital | Chan,Alicia | Australia | South Australia | Adelaide |
| 152 | St. John of God Subiaco Hospital | McQuillan,Brendan | Australia | Western Australia | Crawley |
| 153 | Instituto de Pesquisa clinica de Campinas | Saraiva,Jose Francisco Kerr | Brazil | Sao Paulo | Campinas |
| 154 | CAPED Centro Avancado Pesquisa e Diagnostica | Schwartzmann,Pedro Vellosa | Brazil | Sao Paulo | ribeirao preto |
| 155 | Universidade Federal de Goias | Freitas,Aguinaldo F. | Brazil | Goias | Goiania |
| 156 | PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR | Moura,Lidia Zytynski | Brazil | Parana | Curitiba |
| 157 | Hospital Pro-Cardiaco | Montera,Marcelo | Brazil | Rio de Janeiro | Rio de janeiro |
| 158 | Incor - Instituto do Coracao | Marcondes-Braga,Fabiana G. | Brazil | Sao Paulo | Sao José dos Campos |
| 159 | Hospital das Clínicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (USP) - HCFMRP | Simoes,Marcus Vinicius | Brazil | Sao Paulo | Ribeirao Preto |
| 160 | Hospital de Messejana Dr Carlos Alberto Studart Gomes | Souza,joao DAVID | Brazil | Ceara | Fortaleza |
| 161 | Centro de Pesquisa Clinica do Coracao | SILVEIRA,FáBIO SERRA | Brazil | Sergipe | ARACAJU |
| 162 | Hospital Mae de Deus | Manenti,Euler Roberto Fernandes | Brazil | Rio Grande do Sul | Porto Alegre |
| 163 | G A Research Associates | Bourgeois,Ronald Leonard | Canada | NB | Moncton |
| 164 | Montreal General Hospital | Huynh,Thao Thanh | Canada | QC | Montreal |
| 165 | Kawartha Cardiology Clinical Trials | Hartleib,Michael C. | Canada | ON | Peterborough |
| 166 | Private Practice - Dr. James Cha | Cha,James Y | Canada | ON | Oshawa |
| 167 | Oakville Cardiovascular Research LP | Heffernan,Michael | Canada | ON | Oakville |
| 168 | Cambridge Cardiac Care Centre | Pandey,A. Shekhar | Canada | ON | Cambridge |
| 169 | Corcare | Mukherjee,Ashok | Canada | ON | Scarborough |
| 170 | Institut de Cardiologie de Montreal | Parent,Marie-Claude | Canada | QC | Montreal |
| 171 | QEII Health Sciences Centre – Victoria General Site | Hayami,Doug | Canada | NS | Halifax |
| 172 | St. Boniface General Hospital | Schaffer,Stephen Allan | Canada | MB | Winnipeg |
| 173 | Unité de Recherche Clinique du CISSS des Laurentides | Pesant,Yves | Canada | QC | St-Jerome |
| 174 | University Of Alberta Hospital | Ezekowitz,Justin | Canada | AB | Edmonton |
| 175 | IUCPQ | OConnor,Kim | Canada | QC | Quebec |
| 176 | Centre Intégré de Santé et de Services Sociaux (CISSS) de Laval / Hopital de la Cité-de-la-Santé | Roy,Annie | Canada | QC | Laval |
| 177 | Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur. | Gosselin,Gilbert | Canada | QC | Terrebonne |
| 178 | PACE Cardiology | Khaykin,Yaariv | Canada | ON | Newmarket |
| 179 | Medicus MFC Research Clinic | Moe,Gordon Willy | Canada | ON | Toronto |
| 180 | Diex Recherche Trois-Rivieres | Sia,Ying Tung | Canada | QC | Trois-Rivieres |
| 181 | Heritage Medical Research Clinic | Howlett,Jonathan G. | Canada | AB | Calgary |
| 182 | Victoria Heart Institute Foundation | Swiggum,Elizabeth | Canada | BC | Victoria |
| 183 | Centre intégré universitaire de santé et de services sociaux de l'Estrie – Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l’Estrie-CHUS) | Lepage,Serge | Canada | QC | Sherbrooke |
| 184 | North York Diagnostic and Cardiac Centre | Verma,Subodh | Canada | ON | North York |
| 185 | Centro De Estudios Cardiologicos Y De Medicina Interna | Lanas,Fernando | Chile | Araucania | Temuco |
| 186 | Clínica Ensenada | Maluenda,Gabriel | Chile | Region M. de Santiago | Santiago |
| 187 | Universidad de Chile - Hospital Clínico Universidad de Chile | Prieto,Juan Carlos | Chile | Region M. de Santiago | Santiago |
| 188 | Enroll SpA | Morales,Luis | Chile | Region M. de Santiago | Providencia |
| 189 | Cardio Sur | Yovaniniz,Patricio | Chile | Region M. de Santiago | Santiago |
| 190 | Complejo Asistencial Dr. Sotero del Rio | Montecinos,Humberto | Chile | Region M. de Santiago | Puente Alto |
| 191 | Clinica Dermacross | Appiani,Franco | Chile | Region M. de Santiago | Santiago |
| 192 | Clinical Research Chile SpA | Mellado,Sergio | Chile | Los Rios | VALDIVIA |
| 193 | Espacio Eme | Cruz,German | Chile | Region M. de Santiago | Nunoa |
| 194 | Hospital y CRS El Pino | Palma Carvajal,Juan Carlos | Chile | Region M. de Santiago | SANTIAGO |
| 195 | Clinica Alemana Osorno | Bourke,Paz Michelle | Chile | Los Lagos | Osorno |
| 196 | IC La Serena Research | Marin,Hugo | Chile | Coquimbo | La Serena |
| 197 | ONCOCENTRO APYS | NOVAJAS,MANUEL ENRIQUE | Chile | Valparaiso | VINA DEL MAR |
| 198 | Centro Cardiovascular Colombiano Clínica Santa María | Saldarriaga,Clara | Colombia | Antioquia | Medellin |
| 199 | IPS Centro Científico Asistencial S.A.S | Accini,Jose Luis | Colombia | Atlantico | Barranquilla |
| 200 | Rodrigo Botero S.A.S | Botero,Rodrigo | Colombia | Antioquia | medellin |
| 201 | Clinica de la Costa S.A.S. | Cadena,Alberto Jose | Colombia | Atlantico | Barranquilla |
| 202 | Fundación Centro de Investigación Clínica CIC | Moncada Corredor,Miguel Alfredo | Colombia | Antioquia | Medellin |
| 203 | Centro de Investigaciones Clinicas SAS | Arana,Camilo | Colombia | Valle del Cauca | Cali |
| 204 | CAIMED CHíA | Rozo Uribe,Ricardo Humberto | Colombia | Cundinamarca | Chía |
| 205 | IPS Médicos Internistas de Caldas | Molina de Salazar,Dora Ines | Colombia | Caldas | Manizales |
| 206 | Instituto Del Corazón De Bucaramanga | Carvajal,Juan Fernando | Colombia | Santander | Bucaramanga |
| 207 | Fundación Cardiovascular de Colombia | Echeverria,Luis Eduardo | Colombia | Santander | Floridablanca |
| 208 | Fundación Valle del Lili | GOMEZ-MESA,JUAN ESTEBAN | Colombia | Valle del Cauca | Cali |
| 209 | Clínica Imbanaco S.A.S | Echeverry,Eduardo Jose | Colombia | Valle del Cauca | Cali |
| 210 | Corazon IPS | Reyes Diaz,Melissa Giannina | Colombia | Atlantico | Barranquilla |
| 211 | KardioBusak s.r.o. | Busak,Ladislav | Czech Republic | Louny | Louny |
| 212 | Institut Klinicke a Experimentalni Mediciny | Melenovsky,Vojtech | Czech Republic | Praha 4 | Prague |
| 213 | Ustredni vojenska nemocnice | Hajsl,Martin | Czech Republic | Praha 6 | Praha |
| 214 | Vojenská Nemocnice Brno | Miklik,Roman | Czech Republic | Jihomoravsky kraj | Brno |
| 215 | Synexus Czech | Skarpova,Iva | Czech Republic | Praha 2 | Prague |
| 216 | MUDr. Libor Nechvatal s.r.o. , Kardiologie | Nechvátal,Libor | Czech Republic | Brno-mesto | Brno |
| 217 | Fakultní nemocnice Brno Bohunice | Radvan,Martin | Czech Republic | Brno-mesto | Brno |
| 218 | Vseobecna fakultni nemocnice v Praze | Belohlavek,Jan | Czech Republic | Praha 2 | Prague |
| 219 | KIGE | Monhart,Zdenek | Czech Republic | Znojmo | Znojmo |
| 220 | Nemocnice Slany | Drasnar,Tomas | Czech Republic | Stredocesky kraj | Slany |
| 221 | Klinika Dr. Pirka | Bolvanska,Nora | Czech Republic | Mlada Boleslav | Mlada Boleslav |
| 222 | Fakultni Nemocnice u sv. Anny v Brne | Krejci,Jan | Czech Republic | Brno-mesto | Brno |
| 223 | Hvidovre Hospital | Hove,Jens Dahlgaard | Denmark | Hovedstaden | Hvidovre |
| 224 | Holbaek Sygehus | Lindhardt,Morten | Denmark | Sjaelland | Holbaek |
| 225 | Slagelse Sygehus | Mikkelsen,Dennis | Denmark | Sjaelland | Slagelse |
| 226 | Sydvestjysk Sygehus Esbjerg | Madsen,Kristian Taekker | Denmark | Syddanmark | Esbjerg |
| 227 | Svendborg Hospital Odense Universitets hospital | Egstrup,Kenneth | Denmark | Syddanmark | Svendborg |
| 228 | Herlev and Gentofte Hospital | Schou,Morten | Denmark | Hovedstaden | Hellerup |
| 229 | Nordsjollands Hospital - Hillerod | Stride,Nis ottesen | Denmark | Hovedstaden | Hillerod |
| 230 | Aarhus Universitetshospital, Skejby | Wiggers,Henrik | Denmark | Midtjylland | Aarhus |
| 231 | Rigshospitalet | Kober,Lars | Denmark | Hovedstaden | Copenhagen |
| 232 | Roskilde Sygehus | Bruun,Niels Eske | Denmark | Sjaelland | Roskilde |
| 233 | Amager Hospital | Bronnum-Schou,Jens | Denmark | Hovedstaden | Kobenhavn S |
| 234 | Regionshospital Nordjylland | Vadmann,Henrik | Denmark | Nordjylland | Hjoerring |
| 235 | Regionshospitalet Viborg | Hollingdal,Malene | Denmark | Midtjylland | Viborg |
| 236 | CHU Rangueil | Galinier,Michel | France | Haute-Garonne | Toulouse |
| 237 | Centre Hospitalier intercommunal de Toulon La Seyne sur Mer | Tartiere,Jean-Michel | France | Var | Toulon |
| 238 | Centre Hospitalier Universitaire de Nice - Hopital Pasteur | Ferrari,Emile | France | Alpes-Maritimes | Nice Cedex 1 |
| 239 | CHU Charles Nicolle | Bauer,Fabrice | France | Seine-Maritime | Rouen |
| 240 | Hopitaux Universitaires Paris Sud - Hopital Bicêtre | Berthelot,Emmanuelle | France | Val-de-Marne | Le Kremlin-Bicetre |
| 241 | Centre Hospitalier Régional Universitaire de Nancy - Hopitaux de Brabois | Girerd,Nicolas | France | Lorraine | Vandoeuvre-lès-Nancy |
| 242 | Centre Hospitalier Louis Pasteur | Dutoiu,Teodora | France | Centre | Le Coudray |
| 243 | CHD Vendee | BOIFFARD,Emmanuel | France | Vendee | la roche sur yon |
| 244 | CHU Bordeaux Haut-Leveque | Picard,Francois | France | Gironde | Pessac |
| 245 | Pitie Salpetriere University Hospital | ISNARD,Richard | France | Paris | Paris |
| 246 | Hospices Civils de Lyon – Hopital Louis Pradel | Mewton,Nathan | France | Rhone | Bron |
| 247 | Marienhaus Klinikum St. Elisabeth Neuwied | Huegl,Burkhard | Germany | Rheinland-Pfalz | Neuwied |
| 248 | Klinikum Leverkusen | Schwimmbeck,Peter Lothar | Germany | Nordrhein-Westfalen | Leverkusen |
| 249 | Kliniken Maria Hilf | Nothofer,Gregor | Germany | Nordrhein-Westfalen | Moenchengladbach |
| 250 | St. Vinzenz-Hospital | Sinning,Jan-Malte | Germany | Nordrhein-Westfalen | Cologne |
| 251 | Klinikum Ludwigshafen | Zeymer,Uwe | Germany | Rheinland-Pfalz | Ludwigshafen |
| 252 | ClinPhenomics CVC GmbH | Winkelmann,Bernhard Rudolf | Germany | Hessen | Frankfurt am Main |
| 253 | Universitaetsklinikum Wuerzburg | Stork,Stefan | Germany | Bayern | Wuerzburg |
| 254 | Gemeinschaftspraxis Dr. Fabian Kramer, Dr. Ulrich Overhoff | Kraemer,Fabian | Germany | Nordrhein-Westfalen | Siegen |
| 255 | Kardiologische Gemeinschaftspraxis | Jeserich,Michael | Germany | Bayern | Nuernberg |
| 256 | Praxis Rankestrasse | Rieker,Werner Albert | Germany | Berlin | Berlin |
| 257 | Katholisches Krankenhaus St. Johann Nepomuk | Ebelt,Henning | Germany | Thuringen | Erfurt |
| 258 | Klinikum Frankfurt Hochst | Kadel,Christoph | Germany | Hessen | Frankfurt am Main |
| 259 | Klinikum Coburg | Mahnkopf,Christian | Germany | Bayern | Coburg |
| 260 | Private Practice - Dr. Nicole Toursarkissian | Toursarkissian,Nicole | Germany | Berlin | Berlin |
| 261 | Cardiologicum Hamburg | Bergmann,Martin W. | Germany | Hamburg | Hamburg |
| 262 | Staedtisches Klinikum Dresden | Schellong,Sebastian | Germany | Sachsen | Dresden |
| 263 | Herzzentrum Dresden GmbH Universitatsklinik | Winzer,Ephraim | Germany | Sachsen | Dresden |
| 264 | Universitatsmedizin Greifswald | Felix,Stephan Burkhard | Germany | Mecklenburg-Vorpommern | Greifswald |
| 265 | Asklepios Klinik Langen | Mittag,Marcus | Germany | Hessen | Langen |
| 266 | Universitaetsklinikum Heidelberg | Frey,Norbert | Germany | Baden-Wurttemberg | Heidelberg |
| 267 | Medizinische Hochschule Hannover | Bauersachs,Johann | Germany | Niedersachsen | Hannover |
| 268 | Hausarztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien | Axthelm,Christoph | Germany | Sachsen | Dresden |
| 269 | DRK Kliniken Berlin - Kopenick | Spencker,Sebastian | Germany | Berlin | Berlin |
| 270 | University Hospital of Alexandroupolis | Tziakas,Dimitrios | Greece | Evros | Alexandroupoli |
| 271 | General Hospital of Athens Hippokratio | Tsioufis,Konstantinos P. | Greece | Attiki | Athens |
| 272 | Konstantopoulio-Patission General Hospital of Nea Ionia | Patsilinakos,Sotirios | Greece | Attiki | Nea Ionia |
| 273 | University Hospital of Ioannina | Naka,Aikaterini | Greece | Ioannina | Ioannina |
| 274 | University General Hospital of Larissa | Triposkiadis,Filippos | Greece | Larisa | Larissa |
| 275 | ATTIKON GENERAL UNIVERSITY HOSPITAL | Filipatos,Gerasimos | Greece | Attiki | Chaidari |
| 276 | European Interbalkan Medical Center | NINIOS,VLASIOS | Greece | Thessaloniki | Thessaloniki |
| 277 | AHEPA University General Hospital of Thessaloniki | ZIAKAS,ANTONIOS | Greece | Anatoliki Makedonia kai Thraki | Athens |
| 278 | Alexandra General Hospital of Athens | Briasoulis,Alexandros | Greece | Attiki | Athens |
| 279 | Hygeia Hospital | Tsougos,Elias | Greece | Attiki | Athens |
| 280 | General Hospital of Athens | KARAVIDAS,APOSTOLOS J | Greece | Attiki | Athens |
| 281 | Clinica Medica | Arango Benecke,Juan Luis | Guatemala | Guatemala | Guatemala |
| 282 | Unidad De Diagnostico Cardiologico | Montenegro Valdovinos,Pablo Carlos | Guatemala | Guatemala | Guatemala |
| 283 | Unidad De Diagnostico Cardiologico | Rodas Diaz,Marco Antonio | Guatemala | Guatemala | Guatemala |
| 284 | Prince of Wales Hospital | Lee,Pui-Wai Alex | 中国香港 | 中国香港 | 中国香港 |
| 285 | Queen Mary Hospital | Hai,Siu Han Jojo | 中国香港 | 中国香港 | 中国香港 |
| 286 | Grantham Hospital | Fan,Katherine | 中国香港 | 中国香港 | 中国香港 |
| 287 | Princess Margaret Hospital | Chan,Ngai-Yin | 中国香港 | 中国香港 | 中国香港 |
| 288 | Gottsegen Gyorgy Országos Kardiovaszkuláris Intézet | Kancz,Sandor | Hungary | Budapest | Budapest |
| 289 | Kistarcsai Flor Ferenc Korhaz | Kirschner,Robert J. | Hungary | Pest | Kistarcsa |
| 290 | Private Practice - Dr. Lakatos Ferenc | Lakatos,Ferenc | Hungary | Bekes | Bekescsaba |
| 291 | Semmelweis Egyetem | Merkely,Béla | Hungary | Budapest | Budapest |
| 292 | Fejér Megyei Szent Gyorgy Egyetemi Oktató Kórház | Noori,Ebrahim | Hungary | Fejer | Szekesfehervar |
| 293 | Szent Rókus Kórház | Papp,Andras Jozsef | Hungary | Budapest | Budapest |
| 294 | Medifarma 98 Kft | Zilahi,Zsolt | Hungary | Szabolcs-Szatmar-Bereg | Nyiregyhaza |
| 295 | Karolina Kórház Rendelointézet | Poor,Ferenc | Hungary | Gyor-Moson-Sopron | 9200 Mosonmagyar |
| 296 | óbudai Egészségügyi Centrum | Kovacs,Istvan | Hungary | Budapest | Budapest |
| 297 | óbudai Egészségügyi Centrum – Zalaegerszeg | Toth,Tunde | Hungary | Zala | Zalaegerszeg |
| 298 | Pécsi Tudományegyetem Klinikai Kozpont | Habon,Tamas | Hungary | Baranya | Pécs |
| 299 | TaNa Med | Takacs,Janos | Hungary | Gyor-Moson-Sopron | Mosonmagyarovar |
| 300 | CoroMed | Konyi,Attila | Hungary | Baranya | Pecs |
| 301 | Tolna Megyei Balassa János Kórház | Benczur,Bela | Hungary | Tolna | Szekszard |
| 302 | DRC Gyógyszervizsgáló Kozpont | Literati-Nagy,Botond | Hungary | Veszprem | Balatonfured |
| 303 | Bacs-Kiskun Varmegyei Oktatokorhaz | Nagy,Andras | Hungary | Bacs-Kiskun | Kecskemet |
| 304 | Szegedi Tudományegyetem Szent-Gyorgyi Albert Klinikai Kozpont | Sepp,Robert | Hungary | Csongrad | Szeged |
| 305 | CMed Rehabilitacios es Diagnosztikai Kozpont | Noori,Ebrahim | Hungary | Fejer | Szekesfehervar |
| 306 | Békés Megyei Kozponti Kórház Pándy Kálmán Tagkórház | Thury,Attila | Hungary | Bekes | Gyula |
| 307 | St. James's Hospital | Murphy,Ross | Ireland | Dublin | Dublin |
| 308 | Connolly Hospital | O Neill,James | Ireland | Dublin | Dublin |
| 309 | University College Hospital - Galway | Smyth,Yvonne | Ireland | Galway | Galway |
| 310 | St. Michaels Hospital | McDonald,Kenneth | Ireland | Dublin | Dun Laoghaire |
| 311 | Galilee Medical Center | Atar,Shaul | Israel | NA | Nahariya |
| 312 | Rabin Medical Center | Ben Gal,Tuvia | Israel | NA | Petah Tikva |
| 313 | Rambam Health Care Campus | Caspi,Oren | Israel | NA | Haifa |
| 314 | Kaplan Medical Center | Goland,Sorel | Israel | NA | Rehovot |
| 315 | Shaare Zedek Medical Center | Hasin,Tal | Israel | NA | Jerusalem |
| 316 | Hillel Yaffe Medical Center | Mohsen,Jameel | Israel | NA | Hadera |
| 317 | Yitzhak Shamir Medical Center | Moravsky,Gil | Israel | NA | Zerifin |
| 318 | Hadassah Medical Center | Zwas,Donna | Israel | NA | Jerusalem |
| 319 | Assuta Ashdod Medical Center | Goldman,Alexander | Israel | NA | Ashdod |
| 320 | Sheba Medical Center | Fardman,Alexander | Israel | NA | Ramat Gan |
| 321 | Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Senni,Michele | Italy | Bergamo | Bergamo |
| 322 | Azienda Ospedaliero Universitaria S.Anna | Fucili,Alessandro | Italy | Ferrara | Cona |
| 323 | Centro Cardiologico Monzino | Agostoni,Piergiuseppe | Italy | Milano | Milano |
| 324 | Azienda Ospedaliera Spedali Civili di Brescia | Nodari,Savina | Italy | Brescia | Brescia |
| 325 | NOC - Nuovo Ospedale dei Castelli | MIDI,PAOLO | Italy | Lazio | ARICCIA |
| 326 | IRCCS San Raffaele Pisana | Volterrani,Maurizio | Italy | Roma | Roma |
| 327 | Fondazione IRCCS Policlinico San Matteo | Scelsi,Laura | Italy | Pavia | Pavia |
| 328 | IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola | Borghi,Claudio | Italy | Emilia-Romagna | Bologna |
| 329 | ASST Grande Ospedale Metropolitano Niguarda | Maloberti,Alessandro | Italy | Lombardia | Milano |
| 330 | Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Carugo,Stefano | Italy | Lombardia | Milano |
| 331 | Cattinara Hospital | Sinagra,Gianfranco | Italy | Friuli-Venezia Giulia | Trieste |
| 332 | Azienda Ospedaliero Universitaria Senese | Palazzuoli,Alberto | Italy | Toscana | Siena |
| 333 | University of Perugia | Ambrosio,Giuseppe | Italy | Umbria | Perugia |
| 334 | Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino | De Ferrari,Gaetano M | Italy | Piemonte | Torino |
| 335 | AOU Policlinico Umberto I | Badagliacca,Roberto | Italy | Lazio | Rome |
| 336 | P.O. | Imazio,Massimo | Italy | Udine | Udine |
| 337 | University Malaya Medical Centre | Zainal Abidin,Imran | Malaysia | Kuala Lumpur | Kuala Lumpur |
| 338 | Sarawak Heart Centre | Ong,Tiong Kiam | Malaysia | Sarawak | Kota Samarahan |
| 339 | Hospital Tengku Ampuan Afzan | Zainal Abidin,Siti Khairani | Malaysia | Pahang | Kuantan |
| 340 | UiTM Sungai Buloh Campus | Raja Shariff,Raja Ezman Faridz | Malaysia | Selangor | Sungai Buloh |
| 341 | Hospital Sultanah Bahiyah | Abdullah,Abd Syukur | Malaysia | Kedah | Alor Setar, Kedah |
| 342 | Hospital Pulau Pinang | SK Abdul Kader,Muhamad Ali Abdul | Malaysia | Pulau Pinang | Georgetown |
| 343 | Hospital Universiti Sains Malaysia | W ISA,W YUS HANIFF | Malaysia | Kelantan | Kota Bharu |
| 344 | Hospital Queen Elizabeth II | Liew,Houng Bang | Malaysia | Sabah | Kota Kinabalu |
| 345 | Hospital Sultanah Nur Zahirah | Ramli,Ahmad Wazi | Malaysia | Terengganu | Kuala Terengganu |
| 346 | Hospital Angeles Xalapa | Mendez Machado,Gustavo Francisco | Mexico | Veracruz | Xalapa |
| 347 | Centro de Atención e Investigación Cardiovascular del Potosí | Arenas León,José Luis | Mexico | San Luis Potosi | San Luis Potosí |
| 348 | Instituto Nacional de Cardiologia Ignacio Chavez | Arias Mendoza,Maria Alexandra | Mexico | Distrito Federal | Mexico City |
| 349 | Consultorio de Medicina Especilizada del Sector Privado | Lopez Rosas,Enrique | Mexico | Veracruz | Xalapa |
| 350 | CIMAB SA de CV | Bazzoni Ruiz,Alberto Esteban | Mexico | Coahuila | Torreon |
| 351 | Centro de Investigacion Clinica de Oaxaca | Perez Ríos,Jesus Antonio | Mexico | Oaxaca | Oaxaca de Juarez |
| 352 | Oaxaca Site Management Organization S.C. | Segura Gonzalez,Armando | Mexico | Oaxaca | Oaxaca |
| 353 | Medivest Centro de Investigación Integral | Salazar Gaytan,Abel | Mexico | Chihuahua | Chihuahua |
| 354 | Medical Care and Research SA de CV | Peralta Rosado,Hilda Reyna | Mexico | Yucatan | Merida |
| 355 | Unidad biomedica avanzada monterrey | Varela Varela,Alberto | Mexico | Nuevo Leon | Monterrey |
| 356 | Centro de Estudios de Alta Especialidad de Sinaloa | Vazquez,Paul Gabriel | Mexico | Sinaloa | Mazatlan |
| 357 | Cardiocent de Guadalajara S.C. | Chavez Michel,Jaime | Mexico | Jalisco | Guadalajara |
| 358 | Centro de Investigacion Cardiovascular y Metabólica | Fajardo Campos,Pedro | Mexico | Baja California | Tijuana |
| 359 | Unidad de Investigacin Clnica Cardiometabolica de Occidente | Illescas Diaz,Jesus Jaime | Mexico | Jalisco | GUADALAJARA |
| 360 | Instituto Jalisciense de Metabolismo | GARCIA,RICARDO | Mexico | Jalisco | GUADALAJARA |
| 361 | Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. | Salazar Lopez,Hector Roman | Mexico | Tamaulipas | Madero |
| 362 | Hospital General de Acapulco | Matadamas,Norberto | Mexico | Guerrero | Acapulco |
| 363 | Unidad Médica para la Salud Integral | Castelán Vargas,Víctor | Mexico | Nuevo Leon | San Nicolas de los Garza |
| 364 | Fundación Cardiovascular de Aguascalientes A.C. | Bayram Llamas,Edmundo Alfredo | Mexico | Aguascalientes | Aguascalientes |
| 365 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Payro,Gerardo | Mexico | Distrito Federal | Mexico |
| 366 | Grupo Ollin Care | Zambrano Ruiz,Eduardo | Mexico | Hidalgo | Pachuca |
| 367 | Centro de Imagen y Tecnología en Intervención Cardiovascular | Ricalde,Alejandro | Mexico | Distrito Federal | Ciudad de México |
| 368 | HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA | RAMIREZ MENDOZA,MARCELO SOSTENES | Mexico | Distrito Federal | CDMX |
| 369 | Hospital de Jésus, I.A.P. | Villeda Espinosa,Efrain | Mexico | Distrito Federal | Mexico City |
| 370 | Christchurch Heart Institute | Troughton,Richard William | New Zealand | Canterbury | Christchurch |
| 371 | Hutt Valley District Health board HVDHB | Ferrier,Katherine | New Zealand | Wellington | Lower Hutt |
| 372 | Dunedin Hospital | Pemberton,James | New Zealand | Otago | Dunedin |
| 373 | Waikato Hospital | Dhakshinamurthy,Vijay Anand | New Zealand | Waikato | Hamilton |
| 374 | North Shore Hospital | Scott,Anthony | New Zealand | Auckland | Auckland |
| 375 | Aotearoa Clinical Trials | Turaga,Mansi | New Zealand | Auckland | Auckland |
| 376 | Auckland City Hospital | Benatar,Jocelyne Rachelle | New Zealand | Auckland | Auckland |
| 377 | Hospital Alberto Sabogal Sologuren | Rodriguez Escudero,Aldo Edwin German | Peru | Qallaw | Bellavista |
| 378 | Hospital Cayetano Heredia | Medina P.,Felix Alvaro | Peru | Lima | Cercado de Lima |
| 379 | Clínica Javier Prado | Lu G.,Libia | Peru | Lima | San Isidro |
| 380 | Clínica Vesalio | CABRERA,JOSE WALTER | Peru | Lima | LIMA |
| 381 | Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud | Godoy Palomino,Armando Lionel | Peru | Muni Metro de Lima | Jesús María |
| 382 | Clínica Providencia | Correa Flores,Roger Martin | Peru | Muni Metro de Lima | San Miguel |
| 383 | Clínica El Golf | Berrospi,Percy | Peru | Lima | Lima |
| 384 | Clínica Belén | Cardoza Anton,Luisa Marleny | Peru | Piura | Piura |
| 385 | Centro de investigacion Clínica Trujillo | Camacho,Luis Alberto | Peru | La Libertad | trujillo |
| 386 | NZOZ Twoja Przychodnia | Pijanowski,Zbigniew | Poland | Lubelskie | Lublin |
| 387 | ETG Warszawa | Skoczylas,Grzegorz | Poland | Mazowieckie | Warszawa |
| 388 | Praktyka Lekarska Lidia Pawlowicz | Pawlowicz,Lidia Joanna | Poland | Kujawsko-pomorskie | Torun |
| 389 | Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu | Szachniewicz,Joanna | Poland | Dolnoslaskie | Wroclaw |
| 390 | Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman | Cymerman,Krzysztof | Poland | Pomorskie | Gdynia |
| 391 | Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. | Zajdel,Wojciech | Poland | Malopolskie | Kraków |
| 392 | Polsko-Amerykańskie Kliniki Serca PAKS Malopolskie Centrum Sercowo-Naczyniowe | Zurakowski,Aleksander | Poland | Malopolskie | Chrzanów |
| 393 | Private Practice - Dr. Robert Witek | Witek,Robert Waldemar | Poland | Malopolskie | Tarnów |
| 394 | Centrum Medyczne Medyk | Mazur,Stanislaw | Poland | Podkarpackie | Rzeszow |
| 395 | NZOZ Centrum Medyczne KERmed | Lugowski,Tomasz | Poland | Kujawsko-pomorskie | Bydgoszcz |
| 396 | Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. | Miklaszewicz,Beata | Poland | Dolnoslaskie | Legnica |
| 397 | SP ZOZ w Pulawach | Gniot,Jacek | Poland | Lubelskie | Pulawy |
| 398 | Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik | Sudnik,Wanda | Poland | Podlaskie | Sokolka |
| 399 | Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu | Skonieczny,Grzegorz | Poland | Kujawsko-pomorskie | Torun |
| 400 | Polsko-Amerykańskie Kliniki Serca | Prokopczuk,Janusz | Poland | Opolskie | Kedzierzyn- Kozle |
| 401 | Cooperativa De Facultad Medica Sanacoop | Toro-Grajales,Ismael | Puerto Rico | PR | Bayamon |
| 402 | Research and Cardiovascular Corp. | Vazquez-Tanus,Jose B. | Puerto Rico | PR | Ponce |
| 403 | Caparra Internal Medicine | Matta Fontanet,Evelyn | Puerto Rico | PR | Río Grande |
| 404 | Private Practice - Dr. Yolanda Figueroa-Torres | Figueroa-Torres,Yolanda | Puerto Rico | PR | Humacao |
| 405 | VA Caribbean Healthcare System | Rodriguez-Ospina,Luis F | Puerto Rico | PR | San Juan |
| 406 | Pokrovskaya Municipal Hospital | Vishnevskiy,Alexander | Russian Federation | Leningradskaya oblast | Saint Petersburg |
| 407 | Pokrovskaya Municipal Hospital | Nikolaev,Dmitry | Russian Federation | Sankt-Peterburg | Saint Petersburg |
| 408 | Clinical Hospital S.R.Mirotvortseva name SSMU | Shvarts,Yury Grigorievich | Russian Federation | Saratovskaya oblast | Saratov |
| 409 | State budgetary Healthcare Institution of the city of Moscow | Meray,Imad | Russian Federation | Moskva | Moscow |
| 410 | Kazan Federal University | Kamalov,Gadel | Russian Federation | Tatarstan, Respublika | Kazan |
| 411 | First Pavlov State Medical University of Saint Petersburg | Volkova,Elena | Russian Federation | Sankt-Peterburg | Saint Petersburg |
| 412 | Volgograd State Medical University | Lopatin,Yury | Russian Federation | Volgogradskaya oblast | Volgograd |
| 413 | Rostov State Medical University | Kastanayan,Alexander | Russian Federation | Rostovskaya oblast | Rostov-on-Don |
| 414 | Ryazan State Medical University named after Academician I.P. Pavlova | Yakushin,Sergey | Russian Federation | Ryazanskaya oblast | Ryazan |
| 415 | Moscow City Clinical Hospital Number 15 | Gordeev,Ivan Gennadievich | Russian Federation | Moskva | Moscow |
| 416 | Ivanovo Regional Healthcare Institution Cardiology Dispensary | Shutemova,Elena | Russian Federation | Ivanovskaya oblast | Ivanovo |
| 417 | Tomsk Scientific Center Research Institute of Cardiology | Ryabov,Vyacheslav | Russian Federation | Tomskaya oblast | Tomsk |
| 418 | City Hospital No. 4 | Zykov,Mikhail | Russian Federation | Krasnodarskiy kray | Sochi |
| 419 | Rostov-on-Don City Emergency Hospital | Khaisheva,Larisa | Russian Federation | Rostovskaya oblast | Rostov- on-Don |
| 420 | Perm Regional Hospital for War Veterans | Koziolova,Natalya A | Russian Federation | Permskiy kray | Perm |
| 421 | Altai Regional Cardiology Clinic | Chumakova,Galina | Russian Federation | Altayskiy kray | Barnaul |
| 422 | Astarta Clinic | Kositsyn,Dmitry Vladimirovich | Russian Federation | Sankt-Peterburg | Sankt-Peterburg |
| 423 | Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo | Kosmacheva,Elena | Russian Federation | Krasnodarskiy kray | Krasnodar |
| 424 | National Medical Research Centre of Cardiology named after Academician E.I. Chazov | Tereschenko,Sergey N. | Russian Federation | Moskva | Moscow |
| 425 | Hadassah Medical | Anikin,Georgiy Stanislavovich | Russian Federation | Moskva | Moscow |
| 426 | First Pavlov State Medical University of Saint Petersburg | Lukyanov,Yury | Russian Federation | Sankt-Peterburg | Sankt-Petrburg |
| 427 | National Clinical Research Center n.a. academician E.N. Meshalkin | Nesmachnyy,Alexey Sergeevich | Russian Federation | Novosibirskaya oblast | Novosibirsk |
| 428 | Omsk Regional Clinical Health Service Number 9 | DRONOV,DMITRY | Russian Federation | Omskaya oblast | OMSK |
| 429 | Clinical Hospital No.2 | Iunonin,Igor | Russian Federation | Yaroslavskaya oblast | Yaroslavl |
| 430 | Surgical Clinic | Belousova,Lidia | Russian Federation | Sankt-Peterburg | Saint-Petersburg |
| 431 | Interregional Clinical Diagnostic Center | Isaeva,Elena Nikolaevna | Russian Federation | Tatarstan, Respublika | Kazan |
| 432 | Institute for Medical Research | Kovalchuk,Evgeniy | Russian Federation | Leningradskaya oblast | Saint Petersburg |
| 433 | Almazov National Medical Research Centre | Sitnikova,Maria | Russian Federation | Leningradskaya oblast | Saint-Petersburg |
| 434 | National Heart Centre Singapore | Sim,Kheng Leng David | Singapore | Central Singapore | Singapore |
| 435 | Tan Tock Seng Hospital | Loh,Seet Yoong | Singapore | Central Singapore | Singapore |
| 436 | National University Heart Centre, Singapore | Lin,Weiqin | Singapore | South West | Singapore |
| 437 | Changi General Hospital | Huang,Weiliang | Singapore | South East | Singapore |
| 438 | TREAD Research | Prozesky,Hans Walter | South Africa | Western Cape | Cape Town |
| 439 | Clinical Trial Systems | Fulat,Muhammed Ameen | South Africa | Gauteng | Pretoria |
| 440 | Universitas Private Hospital | Makotoko,Ellen Makoali | South Africa | Free State | Bloemfontien |
| 441 | Professor Ntsekhe Cardiology Clinic | Ntsekhe,Mpiko | South Africa | Western Cape | Observatory |
| 442 | Wits Clinical Research | Nunkoo,Theema | South Africa | Gauteng | Soweto |
| 443 | Enhancing Care Foundation | Mngqibisa,Rosie | South Africa | Kwazulu-Natal | Durban |
| 444 | Netcare Sunninghill Hospital | KLUG,ERIC QUINTON | South Africa | Gauteng | Johannesburg |
| 445 | Cardiovascular Research Center | Ranjith,Naresh | South Africa | Kwazulu-Natal | Durban |
| 446 | Tiervlei Trial Centre | Mohamed,Zarinah | South Africa | Western Cape | cape town |
| 447 | University of Pretoria - Faculty of Health Sciences | Rheeder,Paul Paul | South Africa | Gauteng | Pretoria |
| 448 | Life Vincent Pallotti Hospital | Horak,Adrian | South Africa | Western Cape | Cape Town |
| 449 | Excellentis Clinical Trial Consultants | Gould,Trevor | South Africa | Western Cape | George |
| 450 | Midrand Medical Centre | Jacovides,Andrew | South Africa | Gauteng | Johannesburg |
| 451 | Paarl Research Centre | Coetzee,Kathleen | South Africa | Western Cape | PAARL |
| 452 | Jongaie Research | De Jong,Douwe Marcus | South Africa | Gauteng | Pretoria |
| 453 | Lenasia Clinical Trial Centre - Johannesburg | Dawood,Riaz Suleman | South Africa | Gauteng | Lenasia |
| 454 | Chungbuk National University Hospital | Cho,Myeong-Chan | Korea (the Republic of) | Chungbuk | Cheongju |
| 455 | Severance Hospital, Yonsei University Health System | Kang,Seok-Min | Korea (the Republic of) | Seoul | Seoul |
| 456 | Pusan National University Hospital | Choi,Jung-Hyun | Korea (the Republic of) | Pusan-Kwangyokshi | Busan |
| 457 | Chungnam national university hospital | Jeong,Jin-Ok | Korea (the Republic of) | Taejon-Kwangyokshi | Daejeon |
| 458 | Wonju Severance Christian Hospital | Yoo,Byung-Su | Korea (the Republic of) | Kang-won-do | Wonju |
| 459 | Hallym University Sacred Heart Hospital | Jo,Sang-Ho | Korea (the Republic of) | Kyonggi-do | Anyang |
| 460 | Seoul National University Hospital | CHO,HYUN-JAI | Korea (the Republic of) | Seoul | jongno-gu |
| 461 | Chonnam National University Hospital | Kim,Kye Hun | Korea (the Republic of) | Jeonranamdo | Gwangju |
| 462 | Gachon University Gil Medical Center | Chung,Wook-Jin | Korea (the Republic of) | Incheon | Namdong-gu |
| 463 | CHUS - Hospital Clinico Universitario | Gonzalez-Juanatey,Jose Ramon | Spain | La Coruna | Santiago de compostela |
| 464 | Hospital Universitario Virgen de Valme | Reyes Dominguez,Antonio | Spain | Andalucia | Sevilla |
| 465 | Hospital Quiron Barcelona | Cereto Castro,Fernando | Spain | Cataluna | Barcelona |
| 466 | HOSPITAL CLINICO DE VALENCIA | Nunez Villota,Julio | Spain | Valenciana, Comunitat | Valencia |
| 467 | Hospital Universitari Vall d'Hebron | Mendez Fernandez,Ana Belen | Spain | Cataluna | Barcelona |
| 468 | Hospital Universitari de Bellvitge | Gonzalez Costello,Jose | Spain | Barcelona | Hospitalet de Llobregat |
| 469 | Hospital Clinico San Carlos | GOIRIGOLZARRI ARTAZA,JOSEBE | Spain | Madrid, Comunidad de | MADRID |
| 470 | Hospital Universitario Ramón y Cajal | Alvarez Garcia,Jesus | Spain | Madrid, Comunidad de | MADRID |
| 471 | Parc de Salut Mar - Hospital del Mar | Morales Murillo,Ronald Octavio | Spain | Barcelona | Barcelona |
| 472 | Hospital Germans Trias i Pujol | Bayes Genis,Antoni | Spain | Barcelona | Badalona |
| 473 | Hospital Universitario La Paz | Moreno,Raúl | Spain | Madrid | Madrid |
| 474 | CHUAC-Complejo Hospitalario Universitario A Coruna | Crespo Leiro,Maria Generosa | Spain | La Coruna | A Coruna |
| 475 | Sahlgrenska Universitetssjukhuset | Bergh,Niklas | Sweden | Vastra Gotalands lan | Goteborg |
| 476 | Universitetssjukhuset Orebro | Szabó-Soderberg,Barna | Sweden | Orebro lan | Orebro |
| 477 | Clemenstorgets Hjartmottagning | Lindholm,Carl-Johan | Sweden | Skane lan | Lund |
| 478 | Falu Lasarett | Svedberg,Niclas | Sweden | Dalarnas lan | Falun |
| 479 | Vastmanlands Sjukhus Vasteras | LONNBERG,INGEMAR | Sweden | Vastmanlands lan | Vasteras |
| 480 | Skanes Universitetssjukhus Lund | Braun,Oscar | Sweden | Skane lan | Lund |
| 481 | Karolinska Universitetssjukhuset Solna | Najjar,Emil | Sweden | Stockholms lan | Stockholm |
| 482 | Skelleftea Lasarett | Lind,Marcus | Sweden | Vasterbottens lan | Skelleftea |
| 483 | Aleris Specialistvard Sabbatsberg | Rasmanis,Gundars | Sweden | Stockholms lan | Stockholm |
| 484 | Akardo Med Site | Olsson,Ake | Sweden | Stockholms lan | Stockholm |
| 485 | Taipei Veterans General Hospital | Chiang,Chern-En | 中国台湾 | 台湾省 | 台北市 |
| 486 | Hsinchu Mackay Memorial Hospital | Liu,Ming-En | 中国台湾 | 台湾省 | 新竹市 |
| 487 | Chang Gung Medical Foundation-Linkou Branch | Hsieh,I-Chang | 中国台湾 | 台湾省 | 桃园市 |
| 488 | Taichung Veterans General Hospital | Huang,Jin-Long | 中国台湾 | 台湾省 | 台中市 |
| 489 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Lin,Tsung-Hsien | 中国台湾 | 台湾省 | 高雄市 |
| 490 | Changhua Christian Hospital | Hsia,Chien-Hsun | 中国台湾 | 台湾省 | 彰化市 |
| 491 | Eskisehir Osmangazi University | Cavusoglu,Yuksel | Turkey | Eskisehir | Eskisehir |
| 492 | Ankara Bilkent Sehir Hastanesi | Tak,Bahar Tekin | Turkey | Ankara | Ankara |
| 493 | Dokuz Eylul Universitesi Hastanesi | YILMAZ,MEHMET BIRHAN | Turkey | Izmir | Izmir |
| 494 | Mersin University | Celik,Ahmet | Turkey | Mersin | Mersin |
| 495 | Baskent üniversitesi Istanbul Hastanesi | Altay,Hakan | Turkey | Istanbul | Istanbul |
| 496 | Afyon Kocatepe üniversitesi Tip Fakültesi | Onrat,Ersel | Turkey | Afyonkarahisar | Afyonkarahisar |
| 497 | Medical Park zmir Hastanesi | altin,cihan | Turkey | Izmir | Izmir |
| 498 | Kocaeli üniversitesi | Sahin,Tayfun | Turkey | Kocaeli | Kocaeli |
| 499 | Hacettepe Universite Hastaneleri | Kaya,Ergun Baris | Turkey | Ankara | Ankara |
| 500 | Istanbul University Cerrahpasa Medical School Internal Diseases Institute | Yigit,Zerrin | Turkey | Istanbul | Istanbul |
| 501 | Dr. Siyami Ersek Gogüs Kalp Ve Damar Cerrahisi Egitim Ve Arastirma Hastanesi | Yildirimturk,Ozlem | Turkey | Istanbul | Istanbul |
| 502 | Antalya Egitim ve Arastirma Hastanesi | Genc,Ahmet | Turkey | Antalya | Antalya |
| 503 | Carmel Medical Practice | Fuat,Ahmet | United Kingdom of Great Britain and Northern Ireland | England | Darlington |
| 504 | Russells Hall Hospital | Barr,Craig Scott | United Kingdom of Great Britain and Northern Ireland | Dudley | Dudley |
| 505 | King's College Hospital | McDonagh,Theresa | United Kingdom of Great Britain and Northern Ireland | England | London |
| 506 | St. George's Hospital | Anderson,Lisa | United Kingdom of Great Britain and Northern Ireland | England | London |
| 507 | Chesterfield Royal Hospital | Cooke,Justin | United Kingdom of Great Britain and Northern Ireland | Derbyshire | Calow |
| 508 | Blackpool Victoria Hospital | Cassidy,Christopher | United Kingdom of Great Britain and Northern Ireland | Lancashire | Blackpool |
| 509 | Craigavon Area Hospital | Moriarty,Andrew | United Kingdom of Great Britain and Northern Ireland | Armagh,Banbridge and Craigavon | Portadown |
| 510 | Ninewells Hospital and Medical School | Mordi,Ify | United Kingdom of Great Britain and Northern Ireland | Angus | Dundee |
| 511 | William Harvey Heart Centre | Saxena,Manish | United Kingdom of Great Britain and Northern Ireland | London, City of | LONDON |
| 512 | University Hospital Coventry & Warwickshire | Banerjee,Prithwish | United Kingdom of Great Britain and Northern Ireland | England | COVENTRY |
| 513 | Prince Charles Hospital | Taylor,Justin | United Kingdom of Great Britain and Northern Ireland | Merthyr Tydfil | Merthyr Tydfil |
| 514 | University Hospital of North Tees | Dewhurst,Matthew Matthew | United Kingdom of Great Britain and Northern Ireland | Stockton-on-Tees | Stockton on Tees |
| 515 | Cumberland Infirmary | Varma,Madhusudhan Chittari | United Kingdom of Great Britain and Northern Ireland | Cumbria | Carlisle |
| 516 | West Cumberland Hospital | Ibrahim,Bassem | United Kingdom of Great Britain and Northern Ireland | Cumbria | Carlisle |
| 517 | Princess of Wales Hospital | Wong,Aaron | United Kingdom of Great Britain and Northern Ireland | Wales | Bridgend |
| 518 | Walsall Manor Hospital | Jaumdally,Rumi | United Kingdom of Great Britain and Northern Ireland | Birmingham | Walsall |
| 519 | The Adam Practice | Moore,Patrick John | United Kingdom of Great Britain and Northern Ireland | Poole | Dorset |
| 520 | Worcestershire Royal Hospital | Wilson,David | United Kingdom of Great Britain and Northern Ireland | Worcestershire | Worcester |
| 521 | Layton Medical Centre | Clark,Rebecca | United Kingdom of Great Britain and Northern Ireland | Blackpool | Blackpool |
| 522 | Ulster Hospital | Donnelly,Patrick | United Kingdom of Great Britain and Northern Ireland | Lisburn and Castlereagh | Belfast |
| 523 | Communal nonprofit enterprise | Kulbachuk,Oleksandr | Ukraine | Zaporizka oblast | Zaporizhzhia |
| 524 | Communal Non-profit Enterprise | Stets,Roman | Ukraine | Zaporizka oblast | Zaporizhzhia |
| 525 | Communal Non-profit Enterprize | Rishko,Mykola | Ukraine | Zakarpatska oblast | Uzhgorod |
| 526 | Communal Enterprise | Yagensky,Andriy | Ukraine | Volynska oblast | Lutsk |
| 527 | Municipal non-profit enterprise Kyiv City Clinical Emergency Hospital of Kyiv Regional Council (Kyiv City State Administration) | Rudenko,Leonid | Ukraine | Kyiv | Kyiv |
| 528 | Medical Center of Limited Liability Company | Reshotko,Dmytro | Ukraine | Kyiv | Kyiv |
| 529 | State Institution National Scientific Center M.D. Strazhesko Institute of Cardiology of National Academy of Medical Sciences of Ukraine | Parkhomenko,Oleksandr | Ukraine | Kyiv | Kyiv |
| 530 | State Institution National Scientific Center M.D. Strazhesko Institute of Cardiology of National Academy of Medical Sciences of Ukraine | Mishchenko,Larysa | Ukraine | Kyivska oblast | Kyiv |
| 531 | Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council | Levchenko,Olena | Ukraine | Odeska oblast | Odesa |
| 532 | Communal non-profit enterprise | Prokhorov,Oleksandr | Ukraine | Kharkivska oblast | Kharkiv |
| 533 | L.T. Mala National Institute of Therapy of NAMS of Ukraine | Isayeva,Ganna | Ukraine | Kharkivska oblast | Kharkiv |
| 534 | Medbud Clinic | Donets,Oleksandra | Ukraine | Kyiv | Kyiv |
| 535 | State Institution National Scientific Center M.D. Strazhesko Institute of Cardiology of National Academy of Medical Sciences of Ukraine | Voronkov,Leonid George | Ukraine | Kyiv | Kyiv |
| 536 | Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrainian Railway | Myshanych,Halyna | Ukraine | Kyivska oblast | Kyiv |
| 537 | Scientific and research institute of invalid rehabilitation (education scientific and treatment base) of Vinnytsia National Pirogov Medical University | Shevchuk,Sergii | Ukraine | Vinnytska oblast | Vinnitsya |
| 538 | Communal Enterprise | Vyshnyvetskyy,Ivan | Ukraine | Zhytomyrska oblast | Zhytomyr |
| 539 | Municipal Non-Profit Enterprise | Tseluyko,Vira | Ukraine | Kharkivska oblast | Kharkiv |
| 540 | Khmelnytskyi Regional Cardiovascular Center | Klantsa,Andrii | Ukraine | Khmelnytska oblast | Khmelnytskyy |
| 541 | Communal nonprofit enterprise | Kulyk,Anna | Ukraine | Cherkaska oblast | Cherkassy |
| 542 | Clinical medical and diagnostic center Limited Liability Company | Petrovskyy,Roman | Ukraine | Ivano-Frankivska oblast | Ivano-Frankivsk |
| 543 | Municipal Non-commercial Enterprise | Vakaliuk,Igor | Ukraine | Ivano-Frankivska oblast | Ivano-Frankivsk |
| 544 | Communal non-profit enterprise | Zhurba,Svitlana | Ukraine | Cherkaska oblast | Cherkasy |
| 545 | State Institution National Scientific Center M.D. Strazhesko Institute of Cardiology of National Academy of Medical Sciences of Ukraine | Sychov,Oleg | Ukraine | Kyiv | Kyiv |
| 546 | L.T. Mala National Institute of Therapy of NAMS of Ukraine | Rudyk,Iurii | Ukraine | Kharkivska oblast | Kharkiv |
| 547 | Kharkiv Railway Clinical Hospital №1 of Branch | Kamenska,Ellina | Ukraine | Kharkivska oblast | Kharkiv |
| 548 | Communal non-profit enterprise “Consultative and Diagnostic Centre” of Pechersk District | Trubina,Svitlana | Ukraine | Kyiv | Kyiv |
| 549 | Centro de Investigaciones Metabólicas (CINME) | Romero Zarante,Angela Maria | Argentina | CABA | Buenos Aires |
| 550 | Centro de Investigaciones Clinicas del Litoral | Hominal,Miguel | Argentina | Santa Fe | Santa Fe |
| 551 | Fundacion Estudios Clinicos | Vottero,Ezequiel Hector | Argentina | Santa Fe | Rosario |
| 552 | DIM Clínica Privada | Montana,Oscar Romano | Argentina | Buenos Aires | Ramos Mejía |
| 553 | Instituto de Investigaciones Clinicas Zarate | Vico,Marisa Liliana | Argentina | Buenos Aires | San Nicolás de Los Arroyos |
| 554 | Centro Médico Viamonte | Aizenberg,Diego | Argentina | CABA | BUENOS AIRES |
| 555 | CEDIC | Arakaki,Diego Alejandro | Argentina | Buenos Aires | CABA |
五、伦理委员会信息
| 序号 | 名称 | 审查结论 | 批准日期/备案日期 |
|---|---|---|---|
| 1 | 复旦大学附属中山医院医学伦理委员会 | 同意 | 2021-11-24 |
| 2 | 复旦大学附属中山医院医学伦理委员会 | 同意 | 2022-11-14 |
六、试验状态信息
1、试验状态
进行中 （招募完成）
2、试验人数
| 目标入组人数 | 国内: 360 ； 国际: 6000 ； |
|---|---|
| 已入组人数 | 国内: 370 ； 国际: 5801 ； |
| 实际入组总人数 | 国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息； |
3、受试者招募及试验完成日期
| 第一例受试者签署知情同意书日期 | 国内：2022-04-29； 国际：2021-11-02； |
|---|---|
| 第一例受试者入组日期 | 国内：2022-05-10； 国际：2021-11-09； |
| 试验完成日期 | 国内：登记人暂未填写该信息； 国际：登记人暂未填写该信息； |
七、临床试验结果摘要
| 序号 | 版本号 | 版本日期 |
|---|---|---|
| 暂未填写此信息 | ||
泰必达原创。发布者：泰健康，转转请注明出处：https://taibida.com/lczm/93538.html
1.请注意，本站提供的医学产品信息并不完整，不能代替有资格的医疗专业人士所提供的咨询意见，不构成任何医疗建议或诊断。相关问题请咨询您的主治医生获得更多的帮助。本站内容作为纯介绍性信息仅供参考。 2.如有错误请联系客服修正，感谢您的支持和反馈！
